Recombinant Non-capsid protein NS-1 (Tagged)
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Recombinant Non-capsid protein NS-1 (Tagged) is a Human parvovirus B19 isolate AU Fragment protein, in the 1 to 255 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
View Alternative Names
Initiator protein NS1, NS1, NCVP1, Non-capsid protein NS-1, Non-structural protein 1, Non-structural protein NS1
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Non-capsid protein NS-1 (Tagged) (AB225595)
Discontinuous SDS-PAGE (Tris-Glycine gel) (reduced) with 5% enrichment gel and 15% separation gel.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
NS1 is essential in modulating the host's immune response and assisting viral replication. NS1 can interact with host factors and often forms homodimers but may also exist in high-molecular-weight complexes in specific cellular environments. These interactions encourage the virus's ability to evade the immune system while supporting viral replication processes. Its multifaceted function allows it to be secreted into the extracellular space affecting various cellular pathways and immune components.
Pathways
The NS1 protein actively impacts the host's complement pathway and toll-like receptor signaling pathways. Through its interaction with complement proteins NS1 inhibits complement activation enhancing viral survival. Furthermore NS1 can influence pathways involving toll-like receptors which are critical for initiating immune responses. In these pathways NS1's interaction with immune mediators like STAT1 illustrates its importance in modifying the host's response to infection aiding in virus evasion from innate immunity.
Specifications
Form
Liquid
General info
Function
Multifunctional protein essential for viral DNA replication, which cooperatively interacts with the viral DNA origin of replication and transactivates several promoters including the viral p6 promoter. Binds the origin of replication and performs an endonucleolytic nick within a conserved sequence in the viral genome, thereby initiating the rolling circle replication (RCR). Participates in the transcriptional regulation the viral p6 promoter that regulates all viral transcripts and the cellular CDN1A or IL6 promoters. Transactivates several host promoters some of which induce the S cell cycle phase for the production of host replicative proteins. Up-regulates the expression of host E2F4 and E2F5 and interacts with both these factors thereby inhibiting the host cell cycle G2/M transition. This arrest promotes apoptosis for viral release.
Sequence similarities
Belongs to the parvoviruses initiator protein NS1 family.
Subcellular localisation
Host nucleus
Target data
Complementary Products
Product promise
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