Recombinant Phosphinotricin Acetyl Transferase protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Phosphinotricin Acetyl Transferase also known as PAT serves a mechanical role in the inactivation of phosphinothricin an active component in some herbicides. PAT catalyzes the transfer of an acetyl group from acetyl-CoA to phosphinothricin effectively neutralizing it. The approximate mass of PAT is 21 kDa. It is often expressed in genetically modified crops enabling them to tolerate certain herbicides that include phosphinothricin as an active ingredient.

Biological function summary

Phosphinotricin acetyl transferase contributes to herbicide resistance. It ensures the detoxification process allowing plants to grow even in the presence of herbicides that inhibit glutamine synthetase. PAT is not typically known to form part of a larger complex like some other enzymes but its activity is important for maintaining plant viability under herbicide pressure. The expression of this enzyme in plants is a form of an inducible stress response to environmental changes.

Pathways

Phosphinotricin acetyl transferase plays an important role in the metabolic pathway for xenobiotic detoxification. This enzyme is pivotal in the acetylation pathway aiding in counteracting herbicide action. PAT works alongside other metabolic enzymes facilitating detoxification although it is not directly interlinked with common metabolic proteins its function highlights the synergistic nature of plant metabolic systems when dealing with external chemical stresses.

Phosphinotricin acetyl transferase's application relates to agricultural practices rather than direct human diseases although indirectly it could affect human health due to its role in food crop production. Increased use of PAT-expressing crops might influence patterns of herbicide use with implications for biodiversity and ecosystem health. No direct connections to specific human-related protein interactions exist as PAT functions and impacts are largely associated with plant biology and crop engineering rather than mammalian systems.