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AB225650

Recombinant P.IB (porB) protein (Tagged)

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(1 Publication)

Recombinant P.IB (porB) protein (Tagged) is a Neisseria meningitidis H44/76 Full Length protein, in the 20 to 331 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

NMBH4476_1982, NMH_2035, porB, Major outer membrane protein P.IB, PIB, Protein IB, Class 3 protein, Porin

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

E6MZM0

Animal free

No

Carrier free

No

Species

Neisseria meningitidis H44/76

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"DVTLYGTIKAGVETSRSVFHQNGQVTEVTTATGIVDLGSKIGFKGQEDLGNGLKAIWQVEQKASIAGTDSGWGNRQSFIGLKGGFGKLRVGRLNSVLKDTGDINPWDSKSDYLGVNKIAEPEARLISVRYDSPEFAGLSGSVQYALNDNAGRHNSESYHAGFNYKNGGFFVQYGGAYKRHHQVQEGLNIEKYQIHRLVSGYDNDALYASVAVQQQDAKLTDASNSHNSQTEVAATLAYRFGNVTPRVSYAHGFKGLVDDADIGNEYDQVVVGAEYDFSKRTSALVSAGWLQEGKGENKFVATAGGVGLRHKF","proteinLength":"Full Length","predictedMolecularWeight":"49.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":331,"aminoAcidStart":20,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"E6MZM0","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein P.IB also referred to as porB or porB/hup is a part of the porin family found in the outer membrane of the bacteria Neisseria gonorrhoeae and Neisseria meningitidis. These porins form channels that allow the passage of small molecules and ions across the membrane. PorB has an approximate molecular mass of 34 kDa and plays an important role in bacterial cell permeability. Its expression is tightly regulated and highly relevant to the survival mechanisms of Neisseria species.
Biological function summary

Porins like P.IB are critical in the exchange of nutrients and waste products across the bacterial membrane. P.IB being part of a pore-forming complex enables these bacteria to adapt to various environmental conditions by controlling the flow of ions and small molecules. The structural arrangement of P.IB aids in interactions with the host immune system impacting pathogenesis and immune evasion. Therefore the presence of P.IB in Neisseria enhances its adaptability and virulence.

Pathways

P.IB interacts significantly in bacterial pathways governing membrane transport. It plays a role in metabolism and ion regulation ensuring the bacteria's survival in diverse environments. Its interaction with human immune system components makes it a target for studying evasion pathways. P.IB is related to other Neisseria porins like PorA and together these proteins facilitate essential processes that are necessary for maintaining bacterial homeostasis.

P.IB is most commonly associated with conditions like gonorrhea and meningococcal meningitis. Its presence in the outer membrane is linked to increased invasiveness of Neisseria gonorrhoeae and Neisseria meningitidis infections. The pathogenic role of P.IB has been connected to its interaction with host proteins and immune defenses emphasizing its importance in studying bacterial virulence and developing treatments. These interactions make P.IB an appealing target for research aiming to develop interventions against these bacterial infections.
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Specifications

Form

Liquid

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General info

Function

Serves as a slightly cation selective porin.

Sequence similarities

Belongs to the Gram-negative porin family.

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Product protocols

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Target data

Serves as a slightly cation selective porin.
See full target information porB
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 20:1693-1701 PubMed32742398

2020

LncRNA MIR4435-2HG inhibits the progression of osteoarthritis through miR-510-3p sponging.

Applications

Unspecified application

Species

Unspecified reactive species

Yingli Liu,Yun Yang,Liangjia Ding,Yuqin Jia,Yuntao Ji
View all publications
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