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AB226238

Recombinant Pollen major allergen 1-1 protein (His tag)

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Recombinant Pollen major allergen 1-1 protein (His tag) is a Ozark white cedar Full Length protein, in the 22 to 367 aa range, expressed in Yeast, with >90%, suitable for SDS-PAGE.

View Alternative Names

Pectate lyase 1, Major pollen allergen Jun a 1

1 Images
SDS-PAGE - Recombinant Pollen major allergen 1-1 protein (His tag) (AB226238)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Pollen major allergen 1-1 protein (His tag) (AB226238)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Yeast

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P81294

Animal free

No

Carrier free

No

Species

Ozark white cedar

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"DNPIDSCWRGDSNWDQNRMKLADCAVGFGSSTMGGKGGDFYTVTSTDDNPVNPTPGTLRYGATREKALWIIFSQNMNIKLKMPLYVAGHKTIDGRGADVHLGNGGPCLFMRKVSHVILHSLHIHGCNTSVLGDVLVSESIGVEPVHAQDGDAITMRNVTNAWIDHNSLSDCSDGLIDVTLGSTGITISNNHFFNHHKVMLLGHDDTYDDDKSMKVTVAFNQFGPNAGQRMPRARYGLVHVANNNYDPWNIYAIGGSSNPTILSEGNSFTAPSESYKKEVTKRIGCESPSACANWVWRSTRDAFINGAYFVSSGKTEETNIYNSNEAFKVENGNAAPQLTKNAGVVT","proteinLength":"Full Length","predictedMolecularWeight":"39.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":367,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"Yeast","accessionNumber":"P81294","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Pollen Major Allergen 1-1 also known as Phl p 1 in grasses and Bet v 1 in birch pollen is a protein involved mechanically in triggering allergic reactions. It has a mass of approximately 17-18 kDa and is primarily expressed in pollen grains. This protein acts as an allergen by binding to Immunoglobulin E (IgE) antibodies on the surface of immune cells leading to the release of histamines and other inflammatory mediators that cause allergic symptoms.
Biological function summary

Pollen Major Allergen 1-1 operates as part of the allergen protein family responsible for initiating immune responses that can vary in severity. This protein can form complexes with IgE an important component of allergic reactions. The allergen's structural attributes including its protein folding and heat stability contribute to its allergenic properties by affecting its recognition and binding affinity to IgE antibodies.

Pathways

This allergen plays a significant role in the immune system's hypersensitivity pathways. Particularly it is active in Type I hypersensitivity reactions which involves the cross-linking of IgE molecules bound to receptors on mast cells and basophils. Related proteins in this pathway include histamine a mediator released from mast cells and various cytokines that amplify the immune response.

Pollen Major Allergen 1-1 is mainly connected to allergic rhinitis and allergic asthma. These conditions result from the immune system's exaggerated response to pollen. Histamine release triggered by the allergen plays an important role in the symptoms seen in these disorders. The allergen's interaction with IgE on immune cells directly links it to these allergy-driven conditions making it a target for therapies aimed at alleviating allergic responses.
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Specifications

Form

Liquid

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General info

Function

Has low pectate lyase activity.

Sequence similarities

Belongs to the polysaccharide lyase 1 family. Amb a subfamily.

Post-translational modifications

N-glycosylated; consists of complex-type N-glycans containing the Lewis a antigen (Galbeta1-3(Fucalpha1-4)GlcNAcbeta1-).

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Product protocols

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Target data

Has low pectate lyase activity.
See full target information Pectate lyase 1
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