Recombinant Rabbit VEGFA protein is a Full Length protein, in the 51 to 511 aa range, expressed in Escherichia coli, with >=90% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >=90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
Y L W L L H A P L L H V S L D S L V A A F S V V F E V L P S S L D I P G S K K E E Q A S T Q L G G V E E E H E A S G V V T R Q L A F V V D A I T N P T L E K E T K T I T R I H K A P K F P S H F G F W K R A E E E R G G K S S G E K S R K T D G V G E R A Q A G E Q R E G P G Q R A A A L T D R Q T D T A P S P S A H L L P G R R P T V D A A A S G G Q Q P E P A P E G G V E G V G A R G I A L K L F V Q L L G C S R S G G V V V R A G G A E P S G A A R S V S S G R E E P P P P P P E E E G E E E G E K E E E R G P R W R L G A G E P G S W T G E A A V C A D S A P A A R A P Q A L A R A S A P G A R G A R G G A E E S G P S R S P S R R G S A S R A G P G R A S E T M N F L L S W V H W S L A L L L Y L H H A K W S Q A A P M A E E G D N K P H E V V K F M E V Y R R S Y C Q P I E T L V D I F Q E Y P D E I E Y I F K P S C V P L V R C G G C C N D E S L E C V P T E E F N V T M Q I M R I K P H Q G Q H I G E M S F L Q H N K C E C R C D K P R R
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Alternative names
Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen, MGC70609, MVCD1, VEGF120, VEGFA_HUMAN, VPF, Vascular endothelial growth factor A, Vascular permeability factor, Vegf, vascular endothelial growth factor, vascular endothelial growth factor A121, vascular endothelial growth factor A165
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Recombinant Rabbit VEGFA protein is a Full Length protein, in the 51 to 511 aa range, expressed in Escherichia coli, with >=90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >=90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Animal free
- No
- Concentration
- Storage buffer
pH: 7.4 - 8
Constituents: 6% Trehalose, 2.9% Sodium chloride, 0.24% Tris
Sequence info
Amino acid sequence
- Y L W L L H A P L L H V S L D S L V A A F S V V F E V L P S S L D I P G S K K E E Q A S T Q L G G V E E E H E A S G V V T R Q L A F V V D A I T N P T L E K E T K T I T R I H K A P K F P S H F G F W K R A E E E R G G K S S G E K S R K T D G V G E R A Q A G E Q R E G P G Q R A A A L T D R Q T D T A P S P S A H L L P G R R P T V D A A A S G G Q Q P E P A P E G G V E G V G A R G I A L K L F V Q L L G C S R S G G V V V R A G G A E P S G A A R S V S S G R E E P P P P P P E E E G E E E G E K E E E R G P R W R L G A G E P G S W T G E A A V C A D S A P A A R A P Q A L A R A S A P G A R G A R G G A E E S G P S R S P S R R G S A S R A G P G R A S E T M N F L L S W V H W S L A L L L Y L H H A K W S Q A A P M A E E G D N K P H E V V K F M E V Y R R S Y C Q P I E T L V D I F Q E Y P D E I E Y I F K P S C V P L V R C G G C C N D E S L E C V P T E E F N V T M Q I M R I K P H Q G Q H I G E M S F L Q H N K C E C R C D K P R R
- Protein length
- Full Length
- Predicted molecular weight
- 65.7 kDa
- Amino acids
- 51 to 511
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Vascular endothelial growth factor A (VEGFA) also known as VEGF or vascular permeability factor (VPF) is a protein that plays a central role in angiogenesis as well as in the growth of blood vessels. The molecular weight of VEGFA varies depending on the isoform typically ranging from 34 to 42 kDa. VEGFA is expressed in many tissues including fibroblasts macrophages endothelial cells and platelets. Its expression levels can increase in response to stimuli like hypoxia or inflammatory cytokines. VEGFA is an important target in research for therapies related to vascular diseases and cancer.
- Biological function summary
VEGFA functions by promoting the proliferation and migration of vascular endothelial cells. It operates both as a homodimer and as part of complex signaling cascades interacting with VEGF receptors on cell surfaces to trigger downstream signals for angiogenesis. This includes endothelial cell growth migration and the new blood vessel formation process. VEGFA's activity is important for physiological processes such as wound healing and embryonic development and it also contributes to pathological conditions through its unregulated expression in diseases.
- Pathways
Many processes involve VEGFA including the PI3K/AKT pathway and the MAPK/ERK pathway. These pathways regulate cell survival growth and differentiation. Other proteins like PLGF (placenta growth factor) and VEGFB often accompany VEGFA in these pathways aiding in distinct but overlapping roles. These interactions are transmitted through binding to VEGF receptors such as VEGFR-1 and VEGFR-2 subsequently activating various signaling cascades necessary for cellular and tissue homeostasis.
- Associated diseases and disorders
VEGFA relates to cancer and age-related macular degeneration among others. In cancer overexpression of VEGFA can lead to excessive angiogenesis supplying blood to tumors and facilitating tumor growth. In age-related macular degeneration upregulation of VEGFA contributes to the progression of the disease by promoting the formation of abnormal blood vessels under the retina. Anti-VEGFA therapies such as anti-VEGF antibodies (e.g. bevacizumab) can target these overexpressed pathways. VEGFA interacts with other proteins like HIF-1α which regulates its expression under hypoxia a common condition in tumors.
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1 product image
SDS-PAGE - Recombinant Rabbit VEGFA protein (ab288551)
SDS PAGE analysis of ab288551.
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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