Recombinant Rabies virus Rabies Matrix Protein (Tagged)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Rabies Matrix Protein also known as the M protein plays a mechanical role in the assembly and budding of the rabies virus. It has a molecular mass of approximately 25 kDa. The protein is chiefly expressed in rabies virions where it interacts with other viral components. Its main function is to organize the wrapping of the viral genome into a mature virion ensuring successful infection of host cells.

Biological function summary

The Rabies Matrix Protein facilitates the structural stability of the rabies virus. It associates with the viral nucleocapsid forming a complex with the glycoproteins and RNA. This complex ensures the proper packaging and release of the virus from the host cell. The protein's ability to interact with host cell and viral components makes it an essential part of the virus lifecycle allowing the virus to efficiently exit the cell while maintaining its infective capabilities.

Pathways

The Rabies Matrix Protein has key interactions within the viral budding pathway and host cell membrane pathway. In the viral budding pathway it cooperates with proteins such as the G protein to modulate the plasma membrane of the host cell leading to the release of mature viruses. It also affects the host cell signaling pathways by interacting with cellular proteins to hijack host functions ensuring the virus can continue its lifecycle.

The Rabies Matrix Protein is closely connected to rabies a lethal zoonotic disease affecting the central nervous system. The protein contributes to the pathogenicity of the rabies virus assisting in evading the host immune response. It also interacts with other viral proteins like the L protein which plays a role in viral replication therefore highlighting its importance in the spread of the disease. The understanding of the matrix protein's role in these interactions is important in developing potential therapeutic interventions against rabies.