Recombinant Rat CD134 / OX40L receptor protein (Fc Chimera) is a Rat Fragment protein, in the 20 to 210 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Fc tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
T V K L N C V K D T Y P S G H K C C R E C Q P G H G M V S R C D H T R D T V C H P C E P G F Y N E A V N Y D T C K Q C T Q C N H R S G S E L K Q N C T P T E D T V C Q C R P G T Q P R Q D S S H K L G V D C V P C P P G H F S P G S N Q A C K P W T N C T L S G K Q I R H P A S N S L D T V C E D R S L L A T L L W E T Q R T T F R P T T V P S T T V W P R T S Q L P S T P T L V A P E G P
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).
Alternative names
CD134, Ox40, Txgp1l, Tnfrsf4, Tumor necrosis factor receptor superfamily member 4, MRC OX40, OX40 antigen, OX40L receptor
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Recombinant Rat CD134 / OX40L receptor protein (Fc Chimera) is a Rat Fragment protein, in the 20 to 210 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Fc tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P15725-1
- Animal free
- No
- Species
- Rat
- Reconstitution
- Reconstitute at 400 µg/mL in water
- Concentration
- Storage buffer
pH: 7.4
Constituents: 5% Trehalose, 0.87% Sodium chloride, 0.75% Glycine, 0.61% Tris, 0.44% L-Arginine
Sequence info
Amino acid sequence
- T V K L N C V K D T Y P S G H K C C R E C Q P G H G M V S R C D H T R D T V C H P C E P G F Y N E A V N Y D T C K Q C T Q C N H R S G S E L K Q N C T P T E D T V C Q C R P G T Q P R Q D S S H K L G V D C V P C P P G H F S P G S N Q A C K P W T N C T L S G K Q I R H P A S N S L D T V C E D R S L L A T L L W E T Q R T T F R P T T V P S T T V W P R T S Q L P S T P T L V A P E G P
- Accession
- P15725
- Protein length
- Fragment
- Predicted molecular weight
- 47.7 kDa
- Amino acids
- 20 to 210
- Nature
- Recombinant
- Tags
- Fc tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CD134 also known as OX40 or TNFRSF4 is a receptor that plays an essential role in immune response regulation. This receptor is part of the tumor necrosis factor receptor (TNFR) superfamily and has a molecular mass of approximately 50 kDa. CD134 is expressed on activated T cells particularly CD4+ T cells and is present on various other immune cells under specific conditions. The receptor binds to the OX40L its ligand which is expressed on antigen-presenting cells such as dendritic cells and B cells.
- Biological function summary
CD134 influences T cell proliferation survival and memory formation being an important component of the immune system's adaptive response. OX40L engagement with CD134 enhances the activation and survival of T cells promoting long-term immunity. This interaction does not form part of a larger complex but functions as a direct signaling mechanism that augments T cell receptor (TCR) signaling leading to increased cytokine production and sustained immune responses essential for controlling infections and cancer.
- Pathways
CD134 signaling intersects with the nuclear factor-kappa B (NF-κB) and phosphoinositide 3-kinase (PI3K) pathways. These pathways play significant roles in regulating immune responses and cell survival. Through the NF-κB pathway CD134 influences gene transcription related to immune activation. It also connects with other immune regulatory proteins such as CD28 which further potentiates T cell responses and enhances effector functions.
- Associated diseases and disorders
CD134 has connections to autoimmune diseases and cancers. Overactivity of the CD134-OX40L pathway can lead to exacerbated autoimmune conditions such as lupus. This receptor has also been implicated in tumor immunity where its activation enhances the anti-tumor response of T cells. CD134 interacts with CTLA-4 another immune checkpoint protein playing a role in balancing immune activation and regulation within these disease contexts.
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1 product image
SDS-PAGE - Recombinant Rat CD134 / OX40L receptor protein (Fc Chimera) (ab221327)
SDS-PAGE analysis of reduced (lane 1) and non-reduced (lane 2) ab221327 staining overnight with Coomassie Blue.
The protein migrates as 66 kDa under reducing conditions and 125 kDa under non-reducing conditions on SDS-PAGE gel.
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