Recombinant Rat Factor D/CFD protein (Tagged) is a Rat Full Length protein, in the 26 to 263 aa range, expressed in Mammalian, with >90% purity and suitable for SDS-PAGE.
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Key facts
- Purity
>90% SDS-PAGE
- Expression system
Mammalian
- Tags
His tag N-Terminus
- Applications
SDS-PAGE
- Biologically active
No
Amino acid sequence
I L G G Q E A M A H A R P Y M A S V Q V N G T H V C G G T L V D E Q W V L S A A H C M D G V T K D E V V Q V L L G A H S L S S P E P Y K H L Y D V Q S V V L H P G S R P D S V E D D L M L F K L S H N A S L G P H V R P L P L Q R E D R E V K P G T L C D V A G W G V V T H A G R R P D V L Q Q L T V S I M D R N T C N L R T Y H D G A I T K N M M C A E S N R R D T C R G D S G G P L V C G D A V E A V V T W G S R V C G N R R K P G V F T R V A T Y V P W I E N V L S G N V S V N V T A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
Alternative names
Complement factor D, Adipsin, C3 convertase activator, Endogenous vascular elastase, Properdin factor D, Df, Adn, Cfd
Recommended products
Recombinant Rat Factor D/CFD protein (Tagged) is a Rat Full Length protein, in the 26 to 263 aa range, expressed in Mammalian, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
>90% SDS-PAGE
- Expression system
Mammalian
- Tags
His tag N-Terminus
- Applications
SDS-PAGE
- Biologically active
No
- Accession
- P32038-1
- Animal free
No
- Species
Rat
- Concentration
- Storage buffer
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
I L G G Q E A M A H A R P Y M A S V Q V N G T H V C G G T L V D E Q W V L S A A H C M D G V T K D E V V Q V L L G A H S L S S P E P Y K H L Y D V Q S V V L H P G S R P D S V E D D L M L F K L S H N A S L G P H V R P L P L Q R E D R E V K P G T L C D V A G W G V V T H A G R R P D V L Q Q L T V S I M D R N T C N L R T Y H D G A I T K N M M C A E S N R R D T C R G D S G G P L V C G D A V E A V V T W G S R V C G N R R K P G V F T R V A T Y V P W I E N V L S G N V S V N V T A
- Accession
- Protein length
Full Length
- Predicted molecular weight
29.8 kDa
- Amino acids
26 to 263
- Nature
Recombinant
- Tags
His tag N-Terminus
Specifications
- Form
Liquid
General info
- Function
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
- Sequence similarities
Belongs to the peptidase S1 family.
- Post-translational modifications
N-glycosylated.
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
This product was previously labelled as Factor D
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Factor D also known as complement factor D or CFD protein is a serine protease involved in the alternative pathway of the complement system. It plays a mechanical role by cleaving factor B when it is bound to C3b forming the active C3 convertase C3bBb. This enzyme is relatively small with a mass of approximately 28.5 kDa. It is mainly expressed in adipose tissue but it can also be found in the blood plasma.
- Biological function summary
Factor D aids the immune system's ability to destroy pathogens. As part of the alternative complement pathway it acts independently and does not associate with larger protein complexes. Its activation of the alternative pathway leads to direct lysis of pathogens therefore contributing to innate immunity.
- Pathways
Factor D participates specifically in the complement activation pathway particularly in the innate immune response. It works closely with other proteins in the complement system such as factor B and C3. This pathway enhances the opsonization and removal of microbes and damaged cells acting in parallel with the classical pathway of the complement system.
- Associated diseases and disorders
Abnormal function or regulation of factor D can relate to chronic inflammation and age-related macular degeneration. Disorders involving factor D may involve excess complement activation leading to tissue damage. The role of factor D in these diseases often connects it to other key complement components such as C3 and factor B which can also become problematic when dysregulated.
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1 product image
SDS-PAGE - Recombinant Rat Factor D/CFD protein (Tagged) (ab226230)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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