Recombinant rat IL-1 alpha protein is a Rat Full Length protein, expressed in Escherichia coli, with >98% purity and suitable for SDS-PAGE, FuncS.
M A P H S F Q N N L R Y K L I R I V K Q E F I M N D S L N Q N I Y V D M D R I H L K A A S L N D L Q L E V K F D M Y A Y S S G G D S K Y P V T L K V S N T Q L F V S A Q G E D K P V L L K E I P E T P K L I T G S E T D L I F F W E K I N S K N Y F T S A A F P E L L I A T K E Q S Q V H L A R G L P S M I D F Q I S
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
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Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
Interleukin-1 alpha, IL-1 alpha, Il1a
Recombinant rat IL-1 alpha protein is a Rat Full Length protein, expressed in Escherichia coli, with >98% purity and suitable for SDS-PAGE, FuncS.
Sterile filtered Greater than 98% pure by HPLC analyses. Endotoxin level is less than 0.1 ng per g (1EU/g).
Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
Belongs to the IL-1 family.
Acetylated within its nuclear localization sequence, which impacts subcellular localization.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
The ED50, determined by the dose-dependent stimulation of murine D10S cells, is < 0.005 ng/ml, corresponding to a specific activity of > 2 x 108 units/mg.
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