Recombinant Rat IL-11RA protein (His tag) is a Rat Fragment protein, in the 24 to 371 aa range, expressed in Baculovirus infected insect, with >85% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >85% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- Baculovirus infected insect cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
T P C P Q A W G P P G V Q Y G Q P G R P V M L C C P G V N A G T P V S W F R D G D S R L L Q G P D S G L G H R L V L A Q V D S R D E G T Y V C R T L D G V F G G M V T L K L G S P P A R P E V S C Q A V D Y E N F S C T W S P G R V S G L P T R Y L T S Y R K K T L P G A E S Q R E S P S T G P W P C P Q D P L E A S R C V V H G A E F W S E Y R I N V T E V N P L G A S T C L L D V R L Q R I L R P D P P Q G L R V E S V P G Y P R R L H A S W T Y P A S W R R Q P H F L L K F R L Q Y R P A Q H P A W S T V E P I G L E E L I T D A V A G L P H A V R V S A R D F L D A G T W S A W S P E A W G T P S T G P L R D E V P D G S R G H E Q K L E A A A Q E D S P A P P S P S L Q P D P R P L D H R D P L E Q V A V L A V E H H H H H H
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
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Target data
Function
Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Soluble interleukin-11 receptor subunit alpha. Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.
Alternative names
Interleukin-11 receptor subunit alpha, IL-11 receptor subunit alpha, IL-11R subunit alpha, IL-11R-alpha, IL-11RA, Il11ra1
Recommended products
Recombinant Rat IL-11RA protein (His tag) is a Rat Fragment protein, in the 24 to 371 aa range, expressed in Baculovirus infected insect, with >85% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >85% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- Baculovirus infected insect cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q99MF4-1
- Animal free
- No
- Species
- Rat
- Concentration
- Storage buffer
pH: 7.4
Constituents: 90% PBS, 10% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
- T P C P Q A W G P P G V Q Y G Q P G R P V M L C C P G V N A G T P V S W F R D G D S R L L Q G P D S G L G H R L V L A Q V D S R D E G T Y V C R T L D G V F G G M V T L K L G S P P A R P E V S C Q A V D Y E N F S C T W S P G R V S G L P T R Y L T S Y R K K T L P G A E S Q R E S P S T G P W P C P Q D P L E A S R C V V H G A E F W S E Y R I N V T E V N P L G A S T C L L D V R L Q R I L R P D P P Q G L R V E S V P G Y P R R L H A S W T Y P A S W R R Q P H F L L K F R L Q Y R P A Q H P A W S T V E P I G L E E L I T D A V A G L P H A V R V S A R D F L D A G T W S A W S P E A W G T P S T G P L R D E V P D G S R G H E Q K L E A A A Q E D S P A P P S P S L Q P D P R P L D H R D P L E Q V A V L A V E H H H H H H
- Accession
- Q99MF4
- Protein length
- Fragment
- Predicted molecular weight
- 39.2 kDa
- Amino acids
- 24 to 371
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Liquid
- Additional notes
Affinity purified
General info
- Function
Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.
- Sequence similarities
Belongs to the type I cytokine receptor family. Type 3 subfamily.
- Post-translational modifications
A short soluble form is also released from the membrane by proteolysis. The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing. mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
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1 product image
SDS-PAGE - Recombinant Rat IL-11RA protein (His tag) (ab219288)
15% SDS-PAGE analysis of 3 μg ab219288.
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