Recombinant Rat IL-11RA protein (His tag C-Terminus)

Specifications

Form

Liquid

Additional notes

Affinity purified

General info

Function

Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.. Soluble interleukin-11 receptor subunit alpha. Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11 : sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 3 subfamily.

Post-translational modifications

A short soluble form is also released from the membrane by proteolysis. The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing. mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3.