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Recombinant rat PAI1 protein (Biotin) is a Rat Full Length protein, in the 24 to 402 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, FuncS.

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Images

SDS-PAGE - Recombinant rat PAI1 protein (Biotin) (AB170081), expandable thumbnail
  • Western blot - Recombinant rat PAI1 protein (Biotin) (AB170081), expandable thumbnail

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE, FuncS

Biologically active

Yes

Conjugation

Biotin

Amino acid sequence

S P L P E S H T A Q Q A T N F G V K V F Q H V V Q A S K D R N V V F S P Y G V S S V L A M L Q L T T A G K T R Q Q I Q D A M G F N I S E R G T A P A L R K L S K E L M G S W N K N E I S T A D A I F V Q R D L E L V Q G F M P H F F K L F R T T V K Q V D F S E V E R A R F I I N D W V E R H T K G M I S D L L A K G A V N E L T R L V L V N A L Y F N G Q W K T P F L E A S T H Q R L F H K S D G S T I S V P M M A Q N N K F N Y T E F T T P D G H E Y D I L E L P Y H G E T L S M F I A A P F E K D V P L S A I T N I L D A E L I R Q W K S N M T R L P R L L I L P K F S L E T E V D L R G P L E K L G M T D I F S S T Q A D F T S L S D Q E Q L S V A Q A L Q K V K I E V N E S G T V A S S S T A I L V S A R M A P T E M V L D R S F L F V V R H N P T E T I L F M G Q L M E P

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Application

FuncS

Reactivity

Reacts

Dilution info

-

Notes

-

Associated Products

Select an associated product type

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Target data

Function

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).

Alternative names

Recommended products

Recombinant rat PAI1 protein (Biotin) is a Rat Full Length protein, in the 24 to 402 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, FuncS.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Applications

SDS-PAGE, FuncS

Biological activity

ab170081 typically contains 50 percent active PAI1.

Conjugation

Biotin

Accession

P20961

Animal free

No

Species

Rat

Concentration
Loading...
Storage buffer

pH: 5
Constituents: 2.34% Sodium chloride, 0.41% Sodium acetate, 0.03% EDTA

Sequence info

Amino acid sequence

S P L P E S H T A Q Q A T N F G V K V F Q H V V Q A S K D R N V V F S P Y G V S S V L A M L Q L T T A G K T R Q Q I Q D A M G F N I S E R G T A P A L R K L S K E L M G S W N K N E I S T A D A I F V Q R D L E L V Q G F M P H F F K L F R T T V K Q V D F S E V E R A R F I I N D W V E R H T K G M I S D L L A K G A V N E L T R L V L V N A L Y F N G Q W K T P F L E A S T H Q R L F H K S D G S T I S V P M M A Q N N K F N Y T E F T T P D G H E Y D I L E L P Y H G E T L S M F I A A P F E K D V P L S A I T N I L D A E L I R Q W K S N M T R L P R L L I L P K F S L E T E V D L R G P L E K L G M T D I F S S T Q A D F T S L S D Q E Q L S V A Q A L Q K V K I E V N E S G T V A S S S T A I L V S A R M A P T E M V L D R S F L F V V R H N P T E T I L F M G Q L M E P

Accession

P20961

Protein length

Full Length

Predicted molecular weight

43 kDa

Amino acids

24 to 402

Nature

Recombinant

Specifications

Form

Liquid

General info

Function

Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity).

Sequence similarities

Belongs to the serpin family.

Storage

Shipped at conditions

Dry Ice

Appropriate short-term storage conditions

-80°C

Appropriate long-term storage conditions

-80°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

This product is an active protein and may elicit a biological response in vivo, handle with caution.

Product promise

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In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
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2 product images

  • SDS-PAGE - Recombinant rat PAI1 protein (Biotin) (ab170081), expandable thumbnail

    SDS-PAGE - Recombinant rat PAI1 protein (Biotin) (ab170081)

    SDS-PAGE analysis of ab170081.
    Lane 1: 3µg ab170081 Reduced

    Lane 2: Rat PAI1 (3µg) + Urokinase (15µg) Reduced

    Lane 3: Molecular weight markers

  • Western blot - Recombinant rat PAI1 protein (Biotin) (ab170081), expandable thumbnail

    Western blot - Recombinant rat PAI1 protein (Biotin) (ab170081)

    Avidin-Alkaline Phosphatase Western Blot analysis of ab170081.
    Lane 1: 0.1µg ab170081 Reduced

    Lane 2: Rat PAI1 (3µg) + Urokinase (2µg) Reduced

    All lanes: Western blot - Recombinant rat PAI1 protein (Biotin) (ab170081)

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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