Recombinant RED protein (Tagged-His Tag)
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Recombinant RED protein (Tagged-His Tag) is a Human Full Length protein, in the 1 to 227 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
View Alternative Names
RED, RER, IK, Protein Red, Cytokine IK, IK factor, Protein RER
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant RED protein (Tagged-His Tag) (AB268919)
SDS-PAGE analysis of ab268919.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
RED functions as an important regulator in erythropoiesis which involves the production of red blood cells. It forms a receptor complex with Janus Kinase 2 (JAK2) a non-receptor tyrosine kinase. When EPO or erythropoietin binds to RED it triggers dimerization and autophosphorylation of JAK2 initiating signal transduction cascades that promote cell survival and proliferation. Through this mechanism RED maintains oxygen homeostasis by regulating red blood cell counts.
Pathways
There are two significant pathways that involve RED. The JAK-STAT pathway is a major component of RED's function as it is activated upon EPO binding. This pathway leads to the transcription of genes that promote erythroid cell development and survival. Additionally RED relates to the PI3K-Akt pathway which influences cell cycle progression and apoptosis prevention. Proteins such as STAT5 and PI3K interact with RED in these pathways enhancing its regulatory roles.
Specifications
Form
Liquid
General info
Function
Involved in pre-mRNA splicing as a component of the spliceosome (PubMed : 28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed : 22351768, PubMed : 24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed : 22351768). Required for normal accumulation of SMU1 (PubMed : 24945353).. (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles.
Sequence similarities
Belongs to the RED family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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