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AB236919

Recombinant Ribosome inactivating protein alpha trichosanthin (Tagged)

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Recombinant Ribosome inactivating protein alpha trichosanthin (Tagged) is a Gua Lou Full Length protein, in the 24 to 270 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

Ribosome-inactivating protein alpha-trichosanthin, Alpha-TCS, rRNA N-glycosidase

1 Images
SDS-PAGE - Recombinant Ribosome inactivating protein alpha trichosanthin (Tagged) (AB236919)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Ribosome inactivating protein alpha trichosanthin (Tagged) (AB236919)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel analysis of ab236919.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

6x His tag N-Terminus SUMO tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P09989

Animal free

No

Carrier free

No

Species

Gua Lou

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"DVSFRLSGATSSSYGVFISNLRKALPNERKLYDIPLLRSSLPGSQRYALIHLTNYADETISVAIDVTNVYIMGYRAGDTSYFFNEASATEAAKYVFKDAMRKVTLPYSGNYERLQTAAGKIRENIPLGLPALDSAITTLFYYNANSAASALMVLIQSTSEAARYKFIEQQIGKRVDKTFLPSLAIISLENSWSALSKQIQIASTNNGQFESPVVLINAQNQRVTITNVDAGVVTSNIALLLNRNNMA","proteinLength":"Full Length","predictedMolecularWeight":"43.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":270,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P09989","tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Ribosome inactivating protein alpha trichosanthin also known as TCS is a type 1 ribosome-inactivating protein (RIP) that disrupts protein synthesis by depurinating adenine residues in ribosomal RNA. This action inhibits the assembly of the ribosome effectively halting protein synthesis. Trichosanthin exhibits a molecular weight of approximately 27 kDa. It is primarily expressed in the plant Trichosanthes kirilowii which belongs to the Cucurbitaceae family.
Biological function summary

Ribosome-inactivating proteins like trichosanthin possess a range of activities beyond protein synthesis inhibition. They participate in antiviral responses and have been investigated for their potential to target specific cellular processes in cancer cells. Trichosanthin does not function as part of a multimeric complex; rather it acts individually to exert its effects on cell machinery making it a subject of interest in cancer and virology research.

Pathways

Trichosanthin impacts cellular pathways that involve protein translation and antiviral defense mechanisms. Within these pathways it associates with cellular stress responses and modulates apoptosis. Trichosanthin is related to other ribosome-inactivating proteins such as ricin and saporin that share mechanistic similarities. These proteins interact with ribosomal components to trigger similar downstream effects and influence cellular homeostasis.

Ribosome inactivating protein alpha trichosanthin displays potential therapeutic effects against certain cancers and viral infections. It has shown promising results in research targeting HIV replication by impairing the virus's ability to hijack host cell machinery. Additionally it may be explored for its roles in modulating pathways involved in certain cancers. The protein's connection with other ribosome-inactivating proteins involves shared potential pathways for therapeutic intervention in diseases such as leukemia.
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Specifications

Form

Liquid

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General info

Function

Inactivates eukaryotic 60S ribosomal subunits.

Sequence similarities

Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily.

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Product protocols

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Target data

Inactivates eukaryotic 60S ribosomal subunits.
See full target information Ribosome-inactivating protein alpha-trichosanthin
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