AB70456

Recombinant S. japonicum GST protein

Name: Recombinant S. japonicum GST protein (ab70456) | Abcam
Brand: Abcam Limited
SKU: AB70456
Price: 190 USD
Availability: InStock
Rating: 4 (1 reviews)

(1 Review)

(15 Publications)

Recombinant S. japonicum GST protein is a Schistosoma japonicum Fragment protein, in the 1 to 226 aa range, expressed in Escherichia coli, with >70%, suitable for SDS-PAGE.

View Alternative Names

Glutathione S-transferase class-mu 26 kDa isozyme, GST 26, Sj26 antigen, SjGST

1 Images

SDS-PAGE - Recombinant S. japonicum GST protein (AB70456)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant S. japonicum GST protein (AB70456)

SDS-PAGE showing GST at approximately 26kDa.

Key facts

Purity

>70%

Expression system

Escherichia coli

Applications

SDS-PAGE

applications

Biologically active

Accession

P08515

Animal free

Carrier free

Species

Schistosoma japonicum

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00174% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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Sequence info

[{"sequence":"MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDLVPRGSPGIHRD","proteinLength":"Fragment","predictedMolecularWeight":"105 kDa","actualMolecularWeight":null,"aminoAcidEnd":226,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P08515","tags":[]}]

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Properties and storage information

Shipped at conditions

Dry Ice

Appropriate short-term storage conditions

-80°C

Appropriate long-term storage conditions

-80°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

False

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GST or Glutathione S-transferase is an enzyme family known for detoxifying endogenous and exogenous compounds through conjugation with glutathione. GSTs are about 23–28 kDa in size and are expressed in various tissues such as the liver kidneys and lungs. The GST proteins play vital roles in cellular processes and are utilized extensively in molecular biology often tagged to proteins to enhance solubility known as GST-tagged proteins.

Biological function summary

GST enzymes participate in critical cellular detoxification processes enhancing the solubility of toxins. As part of these processes GST enzymes do not function as part of a larger complex but are individual actors within the cell. They facilitate the conjugation reactions fundamental to cellular metabolism and detoxification making them essential for maintaining cellular health.

Pathways

GST enzymes contribute significantly to the metabolic breakdown pathways like the xenobiotic metabolism pathway. This pathway involves proteins such as cytochrome P450 enzymes which often function upstream to modify compounds for further GST action. GSTs are important for efficiently detoxifying potentially harmful substances preventing cellular damage.

GSTs have considerable relevance to cancer where their overexpression can confer drug resistance in tumor cells complicating treatment approaches. Additionally these enzymes connect with proteins such as MDR1 influencing multidrug resistance in cancer therapy. GSTs also relate to asthma where altered GST activity can affect the body's response to oxidative stress highlighting the enzyme's role in inflammatory processes.

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Specifications

Form

Liquid

Additional notes

Purified by affinity chromatography

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General info

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.

Sequence similarities

Belongs to the GST superfamily. Mu family.

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Product protocols

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Glutathione S-transferase class-mu 26 kDa isozyme

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Publications (15)

Recent publications for all applications. Explore the full list and refine your search

Autophagy 20:1314-1334 PubMed38174993

2024

Targeting cancer-associated fibroblast autophagy renders pancreatic cancer eradicable with immunochemotherapy by inhibiting adaptive immune resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaozhen Zhang,Mengyi Lao,Hanshen Yang,Kang Sun,Yunfei Dong,Lihong He,Xinchi Jiang,Honghui Wu,Yangwei Jiang,Muchun Li,Honggang Ying,Xinyuan Liu,Jian Xu,Yan Chen,Hanjia Zhang,Ruhong Zhou,Jianqing Gao,Xueli Bai,Tingbo Liang

Nucleic acids research 52:1661-1676 PubMed38084912

2023

A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew D Huber,Shyaron Poudel,Jing Wu,Darcie J Miller,Wenwei Lin,Lei Yang,Monicah N Bwayi,Mary Ashley Rimmer,Rebecca R Florke Gee,Jayaraman Seetharaman,Sergio C Chai,Taosheng Chen

International journal of molecular sciences 24: PubMed37298473

2023

Chondrocyte Thrombomodulin Protects against Osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Kang,Ai-Lun Yang,Chao-Han Lai,Tsan-Ju Chen,Sung-Yen Lin,Yan-Hsiung Wang,Chau-Zen Wang,Edward M Conway,Hua-Lin Wu,Mei-Ling Ho,Je-Ken Chang,Chung-Hwan Chen,Tsung-Lin Cheng

Cell death and differentiation 30:560-575 PubMed36539510

2022

Targeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hanshen Yang,Xiaozhen Zhang,Mengyi Lao,Kang Sun,Lihong He,Jian Xu,Yi Duan,Yan Chen,Honggang Ying,Muchun Li,Chengxiang Guo,Qingsong Lu,Sicheng Wang,Wei Su,Tingbo Liang,Xueli Bai

Cell reports. Medicine 3:100825 PubMed36513070

2022

β-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaofeng Li,Chun Yuan,Jianwu Shi,Hang Kang,Yufei Chen,Yonggang Duan,Jing Jin,Lai Ping Cheung,Tin Chiu Li,Ying Liu,Yugui Cui,Ye Chun Ruan,Xiaohua Jiang,Zhiming Cai,Hsiao Chang Chan,Ling Ji,Xuhui Zeng,Jiaying Liu,Hao Chen,Kin Lam Fok

Nature communications 12:4536 PubMed34315872

2021

NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaozhen Zhang,Xing Huang,Jian Xu,Enliang Li,Mengyi Lao,Tianyu Tang,Gang Zhang,Chengxiang Guo,Xiaoyu Zhang,Wen Chen,Dipesh Kumar Yadav,Xueli Bai,Tingbo Liang

American journal of translational research 12:5525-5537 PubMed33042435

2020

Tetraspanin CD9 interacts with α-secretase to enhance its oncogenic function in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Weiwei Lu,Aihua Fei,Ying Jiang,Liang Chen,Yunkun Wang

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 35:1812-1823 PubMed32329910

2020

Thrombomodulin Functional Domains Support Osteoblast Differentiation and Bone Healing in Diabetes in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chung-Hwan Chen,Chao-Han Lai,Yi-Kai Hong,Jui-Ming Lu,Sung-Yen Lin,Tien-Ching Lee,Lan-Yun Chang,Mei-Ling Ho,Edward M Conway,Hua-Lin Wu,Tsung-Lin Cheng

Molecular cell 71:606-620.e7 PubMed30118680

2018

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.

Applications

Unspecified application

Species

Unspecified reactive species

Jong-Ho Cha,Wen-Hao Yang,Weiya Xia,Yongkun Wei,Li-Chuan Chan,Seung-Oe Lim,Chia-Wei Li,Taewan Kim,Shih-Shin Chang,Heng-Huan Lee,Jennifer L Hsu,Hung-Ling Wang,Chu-Wei Kuo,Wei-Chao Chang,Sirwan Hadad,Colin A Purdie,Aaron M McCoy,Shirong Cai,Yizheng Tu,Jennifer K Litton,Elizabeth A Mittendorf,Stacy L Moulder,William F Symmans,Alastair M Thompson,Helen Piwnica-Worms,Chung-Hsuan Chen,Kay-Hooi Khoo,Mien-Chie Hung

Cell death & disease 9:458 PubMed29686263

2018

BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wondossen Sime,Qiankun Niu,Yasmin Abassi,Katarzyna Chmielarska Masoumi,Reihaneh Zarrizi,Julie Bonne Køhler,Sven Kjellström,Vito Alessandro Lasorsa,Mario Capasso,Haian Fu,Ramin Massoumi

View all publications

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Product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Recombinant S. japonicum GST protein

SDS-PAGE - Recombinant S. japonicum GST protein (AB70456)

Key facts

Purity

Expression system

Tags

Applications

Biologically active

Accession

Animal free

Carrier free

Species

Storage buffer

Complementary Products

Reagents, Controls & Accessories

Secondary Antibodies

Proteins & Peptides

Primary Antibodies

Primary Antibodies

Reactivity data

Sequence info

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Specifications

Form

Additional notes

General info

Function

Sequence similarities

Product protocols

Target data

Publications (15)

Product promise