AB81793

Recombinant S. japonicum GST protein

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(5 Publications)

Recombinant S. japonicum GST protein is a Schistosoma japonicum Full Length protein, in the 1 to 232 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, FuncS.

View Alternative Names

Glutathione S-transferase class-mu 26 kDa isozyme, GST 26, Sj26 antigen, SjGST

1 Images

SDS-PAGE - Recombinant S. japonicum GST protein (AB81793)

SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant S. japonicum GST protein (AB81793)

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Applications

SDS-PAGE, FuncS

applications

Biologically active

Accession

P08515

Animal free

Carrier free

Species

Schistosoma japonicum

Storage buffer

pH: 7.9 Constituents: 20% Glycerol (glycerin, glycerine), 0.75% Potassium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00584% EDTA

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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Sequence info

[{"sequence":"MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDLVPRGSPGIHRD","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":"27 kDa","aminoAcidEnd":232,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P08515","tags":[]}]

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Properties and storage information

Shipped at conditions

Dry Ice

Appropriate short-term storage conditions

-80°C

Appropriate long-term storage conditions

-80°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

False

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GST or Glutathione S-transferase is an enzyme family known for detoxifying endogenous and exogenous compounds through conjugation with glutathione. GSTs are about 23–28 kDa in size and are expressed in various tissues such as the liver kidneys and lungs. The GST proteins play vital roles in cellular processes and are utilized extensively in molecular biology often tagged to proteins to enhance solubility known as GST-tagged proteins.

Biological function summary

GST enzymes participate in critical cellular detoxification processes enhancing the solubility of toxins. As part of these processes GST enzymes do not function as part of a larger complex but are individual actors within the cell. They facilitate the conjugation reactions fundamental to cellular metabolism and detoxification making them essential for maintaining cellular health.

Pathways

GST enzymes contribute significantly to the metabolic breakdown pathways like the xenobiotic metabolism pathway. This pathway involves proteins such as cytochrome P450 enzymes which often function upstream to modify compounds for further GST action. GSTs are important for efficiently detoxifying potentially harmful substances preventing cellular damage.

GSTs have considerable relevance to cancer where their overexpression can confer drug resistance in tumor cells complicating treatment approaches. Additionally these enzymes connect with proteins such as MDR1 influencing multidrug resistance in cancer therapy. GSTs also relate to asthma where altered GST activity can affect the body's response to oxidative stress highlighting the enzyme's role in inflammatory processes.

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Specifications

Form

Liquid

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General info

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.

Sequence similarities

Belongs to the GST superfamily. Mu family.

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Product protocols

Visit the General protocols
Visit the Troubleshooting

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Target data

See full target information Glutathione S-transferase class-mu 26 kDa isozyme

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Autophagy 19:1128-1143 PubMed36093594

2022

A plant virus hijacks phosphatidylinositol-3,5-bisphosphate to escape autophagic degradation in its insect vector.

Applications

Unspecified application

Species

Unspecified reactive species

Haitao Wang,Jianhua Zhang,Haoqiu Liu,Man Wang,Yan Dong,Yijun Zhou,Sek-Man Wong,Kai Xu,Qiufang Xu

mBio 12:e0343121 PubMed34933446

2021

GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation.

Applications

Unspecified application

Species

Unspecified reactive species

Shan Wei,Songjian Lu,Lifan Liang,Xian Wang,Wan Li,Tingting Li,Luping Chen,Enguo Ju,Xinquan Zhang,Zhao Lai,Yufei Huang,Xinghua Lu,Shou-Jiang Gao

Nature metabolism 3:1242-1258 PubMed34504353

2021

A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation.

Applications

Unspecified application

Species

Unspecified reactive species

Li Li,Devon M Conradson,Vinita Bharat,Min Joo Kim,Chung-Han Hsieh,Paras S Minhas,Amanda M Papakyrikos,Aarooran Sivakumaran Durairaj,Anthony Ludlam,Katrin I Andreasson,Linda Partridge,Michael A Cianfrocco,Xinnan Wang

Science advances 6:eaba5136 PubMed32596459

2020

Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Jian Han,Omer An,HuiQi Hong,Tim Hon Man Chan,Yangyang Song,Haoqing Shen,Sze Jing Tang,Jaymie Siqi Lin,Vanessa Hui En Ng,Daryl Jin Tai Tay,Fernando Bellido Molias,Priyankaa Pitcheshwar,Hui Qing Tan,Henry Yang,Leilei Chen

The EMBO journal 39:e103499 PubMed32368833

2020

Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Tatsuo Miyamoto,Kosuke Hosoba,Takeshi Itabashi,Atsuko H Iwane,Silvia Natsuko Akutsu,Hiroshi Ochiai,Yumiko Saito,Takashi Yamamoto,Shinya Matsuura

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Recombinant S. japonicum GST protein

SDS-PAGE - Recombinant S. japonicum GST protein (AB81793)

Key facts

Purity

Expression system

Tags

Applications

Biologically active

Accession

Animal free

Carrier free

Species

Storage buffer

Reactivity data

Sequence info

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Specifications

Form

General info

Function

Sequence similarities

Product protocols

Target data

Publications (5)

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