Recombinant Salmonella typhimurium Protein PrgJ (Tagged)

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Protein PrgJ sometimes referred to as PrgJ serves as an important component of the type III secretion system (T3SS) in certain pathogenic bacteria such as Salmonella and Shigella species. It plays an important mechanical role in forming the needle-like structure that allows these bacteria to inject virulence factors directly into host cells. PrgJ is located in the cytoplasm and sometimes partially in the bacterial membrane. Its molecular mass is approximately 13 kDa making it a small yet functional protein important for structural assembly.

Biological function summary

The assembly of the T3SS involves PrgJ working together with other proteins within the system. PrgJ forms the inner rod of the needle acting as a scaffold to maintain the structure's integrity and ensuring efficient translocation of effector proteins. It participates in forming a complex along with PrgH PrgK and other components. This complex enables bacteria to interact with eukaryotic cells facilitating the delivery of toxins that can manipulate host cellular processes.

Pathways

PrgJ takes part in the bacterial infection pathway involving the type III secretion system. This protein plays an integral role in the secretion of virulence factors that disrupt host pathways leading to infection. Within this system PrgJ associates closely with proteins like PrgI and InvJ harmonizing their activities to ensure effective protein translocation. Additionally PrgJ involvement in this pathway showcases its relationship with central cellular pathways in host organisms highlighting its significance in microbial pathogenesis.

Associated diseases and disorders

PrgJ holds association with conditions like gastroenteritis and enteric fever both caused by pathogenic bacteria utilizing T3SS. The presence of PrgJ in pathogens like Salmonella links it to diseases characterized by severe gastrointestinal infection. It interacts with proteins central to bacterial pathogenicity such as SipA and SipC which facilitate cellular invasion and intracellular survival. Understanding PrgJ function and its role within the T3SS offers insight into developing treatments targeting bacterial infections and potentially mitigating associated diseases.