Recombinant SARS M protein (Coronavirus) is a SARS-CoV Fragment protein, expressed in Escherichia coli and suitable for ELISA, WB.
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
SARS M
5, M, Membrane protein, M protein, E1 glycoprotein, Matrix glycoprotein, Membrane glycoprotein
Recombinant SARS M protein (Coronavirus) is a SARS-CoV Fragment protein, expressed in Escherichia coli and suitable for ELISA, WB.
pH: 7.2 - 7.6
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 9% Urea, 0.395% Tris HCl, 0.0292% EDTA
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.
Belongs to the betacoronaviruses M protein family.
Glycosylated at N-terminus.
Purity: 90% SDS-PAGE
The SARS M protein also known as the membrane protein is an essential component of the severe acute respiratory syndrome coronavirus (SARS-CoV) including SARS-CoV-2 which causes COVID-19. This M protein is a glycoprotein with an approximate mass of 25 to 30 kDa. It is abundantly expressed on the surface of the virions and plays a critical role in virus assembly and morphogenesis by providing a scaffold for the virus envelope. The M protein is one of the three major structural proteins of the virus along with the spike (S) and envelope (E) proteins.
The M protein of the SARS virus facilitates viral assembly and budding processes and interacts with other viral proteins such as the nucleocapsid (N) protein. It also plays a significant role in maintaining the structural stability of the virus. M protein forms homotypic interactions and can also form heterotypic interactions with the E and S proteins contributing to the viral particle assembly. It is not part of a larger cellular complex but is fundamental in forming the viral envelope integrity.
The M protein involvement centers around the virus life cycle particularly virus assembly and replication. It fits into the viral replication and assembly pathway by interacting with the N protein which enhances the efficiency of viral particle formation. Additionally the M protein indirectly influences the host cell's cytokine signaling pathway although it does not directly participate in these pathways it modulates the virus's interactions with the host's immune responses.
M protein connects closely with respiratory illnesses chiefly COVID-19 caused by SARS-CoV-2. The M protein plays a role in the pathogenesis of the disease due to its involvement in viral assembly and infectivity. It indirectly impacts protein-mediated immune responses and inflammatory pathways. Additionally the M protein is epidemiologically linked to SARS as it is a shared structural component of all SARS-related coronaviruses helping in understanding the spread and management of these infections.
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