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AB241389

Recombinant Saxiphilin protein (His tag)

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Recombinant Saxiphilin protein (His tag) is a American Bullfrog Fragment protein, in the 484 to 844 aa range, expressed in Yeast, with >90%, suitable for SDS-PAGE.

View Alternative Names

Saxiphilin, SAX

1 Images
SDS-PAGE - Recombinant Saxiphilin protein (His tag) (AB241389)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Saxiphilin protein (His tag) (AB241389)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab241389.

Key facts

Purity

>90% SDS-PAGE

Expression system

Yeast

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P31226

Animal free

No

Carrier free

No

Species

American Bullfrog

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"AHLPSKNKVRWCTINKLEKMKCDDWSAVSGGAIACTEASCPKGCVKQILKGEADAVKLEVQYMYEALMCGLLPAVEEYHNKDDFGPCKTPGSPYTDFGTLRAVALVKKSNKDINWNNIKGKKSCHTGVGDIAGWVIPVSLIRRQNDNSDIDSFFGESCAPGSDTKSNLCKLCIGDPKNSAANTKCSLSDKEAYYGNQGAFRCLVEKGDVAFVPHTVVFENTDGKNPAVWAKNLKSEDFELLCLDGSRAPVSNYKSCKLSGIPPPAIVTREESISDVVRIVANQQSLYGRKGFEKDMFQLFSSNKGNNLLFNDNTQCLITFDRQPKDIMEDYFGKPYYTTVYGASRSAMSSELISACTIKHC","proteinLength":"Fragment","predictedMolecularWeight":"41.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":844,"aminoAcidStart":484,"nature":"Recombinant","expressionSystem":"Yeast","accessionNumber":"P31226","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Saxiphilin also known as SPH is a monomeric protein with a molecular mass of approximately 100 kDa. Mechanically it functions as a high-affinity binding protein for saxitoxin a potent neurotoxin. Saxiphilin shares structural similarities with transferrin family proteins and displays unique ligand-binding properties. The protein expresses prominently in amphibian serum making it an interesting subject of study relating to toxin resistance and immune response in these organisms.
Biological function summary

Saxiphilin acts as a detoxifying agent against neurotoxins by binding to them and sequestering them away from sensitive neurological targets. Unlike many detoxification processes that involve multi-protein complexes saxiphilin operates independently. Its structural relationship with transferrin suggests it might have a role in iron or other metal ion transport or modulation although the primary focus remains on its toxin-binding activities.

Pathways

Saxiphilin is involved in processes that affect the neurological system's response to toxins. It participates in the regulation of sodium channel blockers by sequestering saxitoxin. While not part of a signaling cascade its activity influences proteins like the voltage-gated sodium channels by preventing toxin binding which is important for maintaining proper nerve function.

Saxiphilin's role in counteracting saxitoxin highlights its potential relevance to conditions like saxitoxin poisoning a severe form of paralytic shellfish poisoning. The binding efficiency of saxiphilin might influence the severity or progression of such poisoning. Additionally because of its structural similarity to transferrin there is a theoretical connection to iron metabolism disorders although the specific involvement remains unclear. Understanding these interactions could offer insights into novel therapeutic approaches for neurotoxin-related disorders.
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Specifications

Form

Liquid

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General info

Function

Binds specifically to the neurotoxin saxitoxin. Its physiological role may be to transport or sequester an endogenous organic molecule other than Fe(3+). It may participate in a detoxification mechanism for neutralizing a microbial toxin.

Sequence similarities

Belongs to the transferrin family.

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Product protocols

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Target data

Binds specifically to the neurotoxin saxitoxin. Its physiological role may be to transport or sequester an endogenous organic molecule other than Fe(3+). It may participate in a detoxification mechanism for neutralizing a microbial toxin.
See full target information Saxiphilin
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