Recombinant Staphylococcus aureus Clumping factor A protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

This protein plays a critical role in the initial stages of S. aureus infection. ClfA is not part of a larger protein complex; instead it functions independently to recognize and bind to fibrinogen a glycoprotein found in blood plasma. This interaction contributes to the bacterium's ability to evade the immune response facilitating persistent colonization and subsequent infection. The direct interaction between ClfA and fibrinogen is essential for S. aureus to adhere to and invade host tissues.

Pathways

This protein is integral to the pathogenesis of Staphylococcus aureus by mediating biofilm formation and host tissue invasion. It is an important player in the bacterial surface components that recognize adhesive matrix molecules (MSCRAMM) pathway which also involves other proteins like fibronectin-binding proteins (FnBPs). ClfA's binding to fibrinogen is just one mechanism within this pathway that contributes to biofilm maturation and persistence of infection. This interaction is a tactical advantage for S. aureus allowing it to evade host defenses and establish infections effectively.