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AB236933

Recombinant Staphylococcus aureus Exfoliative Toxin A/ETA protein (His tag)

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Recombinant Staphylococcus aureus Exfoliative Toxin A/ETA protein (His tag) is a Staphylococcus aureus Full Length protein, in the 39 to 280 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Exfoliative toxin A, Epidermolytic toxin A, eta

3 Images
Mass Spectrometry - Recombinant Staphylococcus aureus Exfoliative Toxin A/ETA protein (His tag) (AB236933)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Staphylococcus aureus Exfoliative Toxin A/ETA protein (His tag) (AB236933)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab236933 could indicate that this peptide derived from E.coli-expressed Staphylococcus aureus Exfoliative Toxin A/ETA.

Mass Spectrometry - Recombinant Staphylococcus aureus Exfoliative Toxin A/ETA protein (His tag) (AB236933)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant Staphylococcus aureus Exfoliative Toxin A/ETA protein (His tag) (AB236933)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab236933 could indicate that this peptide derived from E.coli-expressed Staphylococcus aureus Exfoliative Toxin A/ETA.

SDS-PAGE - Recombinant Staphylococcus aureus Exfoliative Toxin A/ETA protein (His tag) (AB236933)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Staphylococcus aureus Exfoliative Toxin A/ETA protein (His tag) (AB236933)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel analysis of ab236933.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

P09331

Animal free

No

Carrier free

No

Species

Staphylococcus aureus

Storage buffer

pH: 7.2 - 7.4 Constituents: 50% Glycerol (glycerin, glycerine), 43.5% Sodium chloride, 5% Tris HCl, 1.5% Staphylococcus aureus Exfoliative Toxin A/ETA protein

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Exfoliative Toxin A
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Sequence info

[{"sequence":"EVSAEEIKKHEEKWNKYYGVNAFNLPKELFSKVDEKDRQKYPYNTIGNVFVKGQTSATGVLIGKNTVLTNRHIAKFANGDPSKVSFRPSINTDDNGNTETPYGEYEVKEILQEPFGAGVDLALIRLKPDQNGVSLGDKISPAKIGTSNDLKDGDKLELIGYPFDHKVNQMHRSEIELTTLSRGLRYYGFTVPGNSGSGIFNSNGELVGIHSSKVSHLDREHQINYGVGIGNYVKRIINEKNE","proteinLength":"Full Length","predictedMolecularWeight":"30.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":280,"aminoAcidStart":39,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P09331","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Exfoliative Toxin A often referred to as ETA or exfoliative toxins is a powerful bacterial protease. Its molecular mass is approximately 27 kDa. Exfoliative Toxin A is expressed by Staphylococcus aureus particularly strains involved in skin infections. This toxin is known for cleaving desmoglein-1 a calcium-dependent cell adhesion molecule in the skin leading to epidermal detachment.
Biological function summary

Exfoliative toxins threaten the integrity of the skin barrier by targeting desmoglein-1 which compromises cellular adhesion within the epidermis. This specific action does not associate Exfoliative Toxin A with any larger protein complexes but rather with specialized pathways directly targeting epidermal cohesion. The cleavage of desmoglein-1 by ETA is significant in the pathogenic strategies of Staphylococcus aureus to cause skin exfoliation.

Pathways

Activities of Exfoliative Toxin A are integral to the pathogenesis of skin exfoliative conditions through the epidermal-dermal disruption pathway. This toxin associates with the serine protease family which modulates proteolytic pathways responsible for tissue damage and inflammation. Its action reverberates through pathways that involve proteins like desmoglein-1 emphasizing the complexity of cellular adhesion and skin integrity pathways.

Exfoliative toxin A exhibits a strong correlation with Staphylococcal Scalded Skin Syndrome (SSSS) and impetigo. These conditions are notable for their disruption of skin architecture and extensive blistering. Exfoliative Toxin A's interaction with desmoglein-1 plays a pivotal role in the pathophysiology of these diseases leading to significant epidermal peeling and vulnerability to secondary infections.
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Specifications

Form

Liquid

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General info

Function

Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS).

Sequence similarities

Belongs to the peptidase S1B family.

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Product protocols

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Target data

Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS).
See full target information eta

Additional targets

Exfoliative Toxin A/ETA
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