Recombinant TTR Protein (His tag)

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Attractin also known as ATRN is a multifunctional protein with a molecular weight of approximately 175 kDa. It plays a role in the nervous system and immune functions. Attractin has the ability to bind melanocortins and is expressed in a variety of tissues notably in the brain blood and immune cells. This protein exists both in a membrane-bound form and a soluble form which results from an alternate splicing and shedding process.

Biological function summary

Attractin involves in controlling cell interactions in the immune system. It forms part of complexes on cell surfaces that affect leukocyte adhesion and migration. This protein modulates T-cell interactions which influences immune responses and facilitates cell communication. It may also have roles in neuroendocrine signaling suggesting its involvement in the communication between neurons and endocrine tissues.

Pathways

The presence of Attractin influences cell signaling pathways that regulate immune responses and cell adhesion. It interacts with the melanocortin pathway which involves melanocortin receptors and is critical for regulating inflammatory responses. Attractin also associates with proteins such as chemokines that mediate cell signaling involved in immune response and neuroinflammation pathways.

Associated diseases and disorders

Attractin has connections to neurological and autoimmune disorders. Mutations in the Attractin gene link to neurological conditions such as seizure disorders where it contributes to abnormal neuron signaling. Additionally there is a relationship with autoimmune disorders where dysregulation of Attractin function can lead to enhanced leukocyte activity. Through its role in these conditions Attractin interfaces with other proteins like CD44 in impacting immune system dysfunction.