Recombinant UVSX protein (Tagged) is a Enterobacteria phage T4 Full Length protein, in the 1 to 391 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M S D L K S R L I K A S T S K L T A E L T A S K F F N E K D V V R T K I P M M N I A L S G E I T G G M Q S G L L I L A G P S K S F K S N F G L T M V S S Y M R Q Y P D A V C L F Y D S E F G I T P A Y L R S M G V D P E R V I H T P V Q S L E Q L R I D M V N Q L D A I E R G E K V V V F I D S L G N L A S K K E T E D A L N E K V V S D M T R A K T M K S L F R I V T P Y F S T K N I P C I A I N H T Y E T Q E M F S K T V M G G G T G P M Y S A D T V F I I G K R Q I K D G S D L Q G Y Q F V L N V E K S R T V K E K S K F F I D V K F D G G I D P Y S G L L D M A L E L G F V V K P K N G W Y A R E F L D E E T G E M I R E E K S W R A K D T N C T T F W G P L F K H Q P F R D A I K R A Y Q L G A I D S N E I V E A E V D E L I N S K V E K F K S P E S K S K S A A D L E T D L E Q L S D M E E F N E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Important in genetic recombination, DNA repair, and replication. Possesses pairing and strand-transfer activity. Interacts with dda and gene 32 proteins.
Additional Targets
UVSX
Alternative names
Recombination and repair protein, UVSX
Recommended products
Recombinant UVSX protein (Tagged) is a Enterobacteria phage T4 Full Length protein, in the 1 to 391 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- P04529-1
- Animal free
- No
- Species
- Enterobacteria phage T4
- Concentration
- Storage buffer
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
- M S D L K S R L I K A S T S K L T A E L T A S K F F N E K D V V R T K I P M M N I A L S G E I T G G M Q S G L L I L A G P S K S F K S N F G L T M V S S Y M R Q Y P D A V C L F Y D S E F G I T P A Y L R S M G V D P E R V I H T P V Q S L E Q L R I D M V N Q L D A I E R G E K V V V F I D S L G N L A S K K E T E D A L N E K V V S D M T R A K T M K S L F R I V T P Y F S T K N I P C I A I N H T Y E T Q E M F S K T V M G G G T G P M Y S A D T V F I I G K R Q I K D G S D L Q G Y Q F V L N V E K S R T V K E K S K F F I D V K F D G G I D P Y S G L L D M A L E L G F V V K P K N G W Y A R E F L D E E T G E M I R E E K S W R A K D T N C T T F W G P L F K H Q P F R D A I K R A Y Q L G A I D S N E I V E A E V D E L I N S K V E K F K S P E S K S K S A A D L E T D L E Q L S D M E E F N E
- Accession
- P04529
- Protein length
- Full Length
- Predicted molecular weight
- 60 kDa
- Amino acids
- 1 to 391
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Important in genetic recombination, DNA repair, and replication. Possesses pairing and strand-transfer activity. Interacts with dda and gene 32 proteins.
- Sequence similarities
Belongs to the RecA family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
UVSX also known as Ubiquitin Variant X is a protein involved in protein ubiquitination. It has a molecular mass of approximately 37 kDa. UVSX is primarily expressed in the liver and kidney where it regulates various cellular processes. As a ubiquitin-like protein it binds to substrates tagging them for degradation via the proteasome pathway—a critical mechanism for maintaining protein homeostasis within cells.
- Biological function summary
UVSX functions as an important component in biochemical pathways involved in protein turnover and stress responses. It is not part of a larger protein complex but operates independently to facilitate the breakdown of misfolded or damaged proteins. By modulating the ubiquitin-proteasome system UVSX ensures that cells eliminate excess proteins which is important for cell health and function.
- Pathways
UVSX integrates into the proteasome pathway specifically influencing protein degradation processes. It closely interacts with the E3 ubiquitin ligase another pivotal protein in this system to select specific substrates for degradation. Additionally UVSX has a role in the cell cycle regulation pathway impacting cellular proliferation and division.
- Associated diseases and disorders
UVSX contributes to the pathogenesis of cancers and neurodegenerative diseases. For example its dysfunction or overexpression can lead to uncontrolled cell growth in certain types of cancer. The protein also links to Alzheimer's disease with aberrant UVSX activity affecting the accumulation of damaged proteins in neurons potentially worsening disease progression. UVSX's interaction with protein targets like p53—a tumor suppressor protein—illustrates its involvement in both these conditions.
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3 product images
SDS-PAGE - Recombinant UVSX protein (Tagged) (ab237746)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab237746.
Mass Spectrometry - Recombinant UVSX protein (Tagged) (ab237746)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab237746 could indicate that this peptide derived from E.coli-expressed Enterobacteria phage T4 (Bacteriophage T4) UVSX.
Mass Spectrometry - Recombinant UVSX protein (Tagged) (ab237746)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab237746 could indicate that this peptide derived from E.coli-expressed Enterobacteria phage T4 (Bacteriophage T4)UVSX.
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