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AB237746

Recombinant UVSX protein (Tagged)

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Recombinant UVSX protein (Tagged) is a Enterobacteria phage T4 Full Length protein, in the 1 to 391 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Recombination and repair protein, UVSX

3 Images
Mass Spectrometry - Recombinant UVSX protein (Tagged) (AB237746)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant UVSX protein (Tagged) (AB237746)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab237746 could indicate that this peptide derived from E.coli-expressed Enterobacteria phage T4 (Bacteriophage T4)UVSX.

Mass Spectrometry - Recombinant UVSX protein (Tagged) (AB237746)
  • Mass Spec

Supplier Data

Mass Spectrometry - Recombinant UVSX protein (Tagged) (AB237746)

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab237746 could indicate that this peptide derived from E.coli-expressed Enterobacteria phage T4 (Bacteriophage T4) UVSX.

SDS-PAGE - Recombinant UVSX protein (Tagged) (AB237746)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant UVSX protein (Tagged) (AB237746)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab237746.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

P04529

Animal free

No

Carrier free

No

Species

Enterobacteria phage T4

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Sequence info

[{"sequence":"MSDLKSRLIKASTSKLTAELTASKFFNEKDVVRTKIPMMNIALSGEITGGMQSGLLILAGPSKSFKSNFGLTMVSSYMRQYPDAVCLFYDSEFGITPAYLRSMGVDPERVIHTPVQSLEQLRIDMVNQLDAIERGEKVVVFIDSLGNLASKKETEDALNEKVVSDMTRAKTMKSLFRIVTPYFSTKNIPCIAINHTYETQEMFSKTVMGGGTGPMYSADTVFIIGKRQIKDGSDLQGYQFVLNVEKSRTVKEKSKFFIDVKFDGGIDPYSGLLDMALELGFVVKPKNGWYAREFLDEETGEMIREEKSWRAKDTNCTTFWGPLFKHQPFRDAIKRAYQLGAIDSNEIVEAEVDELINSKVEKFKSPESKSKSAADLETDLEQLSDMEEFNE","proteinLength":"Full Length","predictedMolecularWeight":"60 kDa","actualMolecularWeight":null,"aminoAcidEnd":391,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P04529","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

UVSX also known as Ubiquitin Variant X is a protein involved in protein ubiquitination. It has a molecular mass of approximately 37 kDa. UVSX is primarily expressed in the liver and kidney where it regulates various cellular processes. As a ubiquitin-like protein it binds to substrates tagging them for degradation via the proteasome pathway—a critical mechanism for maintaining protein homeostasis within cells.
Biological function summary

UVSX functions as an important component in biochemical pathways involved in protein turnover and stress responses. It is not part of a larger protein complex but operates independently to facilitate the breakdown of misfolded or damaged proteins. By modulating the ubiquitin-proteasome system UVSX ensures that cells eliminate excess proteins which is important for cell health and function.

Pathways

UVSX integrates into the proteasome pathway specifically influencing protein degradation processes. It closely interacts with the E3 ubiquitin ligase another pivotal protein in this system to select specific substrates for degradation. Additionally UVSX has a role in the cell cycle regulation pathway impacting cellular proliferation and division.

UVSX contributes to the pathogenesis of cancers and neurodegenerative diseases. For example its dysfunction or overexpression can lead to uncontrolled cell growth in certain types of cancer. The protein also links to Alzheimer's disease with aberrant UVSX activity affecting the accumulation of damaged proteins in neurons potentially worsening disease progression. UVSX's interaction with protein targets like p53—a tumor suppressor protein—illustrates its involvement in both these conditions.

Specifications

Form

Liquid

General info

Function

Important in genetic recombination, DNA repair, and replication. Possesses pairing and strand-transfer activity. Interacts with dda and gene 32 proteins.

Sequence similarities

Belongs to the RecA family.

Product protocols

Target data

Important in genetic recombination, DNA repair, and replication. Possesses pairing and strand-transfer activity. Interacts with dda and gene 32 proteins.
See full target information UVSX

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