Recombinant VP16 protein is a Human herpesvirus 2 strain HG52 protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
| Application | Reactivity | Dilution info | Notes |
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Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Transcriptional activator of immediate-early (IE) gene products (alpha genes). Acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F 1. VP16-induced complex represents a regulatory switch: when it is on, it promotes IE-gene expression and thus lytic infection, and when it is off, it limits IE-gene transcription favoring latent infection (By similarity). May play a role in the aggregation of tegument proteins around nucleocapsids during virus morphogenesis.
VP16
Tegument protein VP16, Alpha trans-inducing protein, Alpha-TIF, ICP25, Vmw65, UL48
Recombinant VP16 protein is a Human herpesvirus 2 strain HG52 protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
pH: 7.9
Constituents: 20% Glycerol (glycerin, glycerine), 0.75% Potassium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00584% EDTA
ab81878 is isolated from an E. coli strain that carries the coding sequence of the fused protein under the control of a T7 promoter.
Transcriptional activator of immediate-early (IE) gene products (alpha genes). Acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F 1. VP16-induced complex represents a regulatory switch: when it is on, it promotes IE-gene expression and thus lytic infection, and when it is off, it limits IE-gene transcription favoring latent infection (By similarity).
Belongs to the herpesviridae tegument protein VP16 protein family.
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