TRPM8 peptide

Specifications

Form

Liquid

General info

Function

Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin therefore plays a central role in the detection of environmental cold temperatures (PubMed : 15306801, PubMed : 15852009, PubMed : 16174775, PubMed : 25559186, PubMed : 37857704). TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel (PubMed : 15306801). In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (By similarity). May plays a role in prostate cancer cell migration (PubMed : 16174775, PubMed : 25559186).. Isoform 2. Negatively regulates menthol- and cold-induced channel activity by stabilizing the closed state of the channel.. Isoform 3. Negatively regulates menthol- and cold-induced channel activity by stabilizing the closed state of the channel.

Sequence similarities

Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM8 sub-subfamily.