AB97212
Goat Anti-Human IgA alpha chain (Alkaline Phosphatase)
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(7 Publications)
Suitable for ICC, IHC-P, ELISA, WB. Cited in 7 publications.
View Alternative Names
Immunoglobulin heavy constant alpha 1, Ig alpha-1 chain C region, Ig alpha-1 chain C region BUR, Ig alpha-1 chain C region TRO, IGHA1
Reactivity data
{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ICC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "IHC-P": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/100 - 1/1000", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/1000 - 1/10000", "notes":"<p>(Primary ELISA)</p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/1000 - 1/10000", "notes":"<p>(Chemiluminescent)</p>" } } }
Properties and storage information
Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antiserum was solid phase adsorbed to ensure class specificity. This antibody was isolated by affinity chromatography using antigen coupled to agarose beads and conjugated to Alkaline Phosphatase (AP).
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: 1.19% HEPES, 0.58% Sodium chloride, 0.2% BSA, 0.0095% Magnesium chloride, 0.00136% Zinc chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Target data
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed : 20176268, PubMed : 22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed : 17576170, PubMed : 20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed : 2241915).
Additional targets
IGHA2
Publications (7)
Recent publications for all applications. Explore the full list and refine your search
BMC infectious diseases 24:1042 PubMed39333882
2024
High transmission of endemic human coronaviruses before and during the COVID-19 pandemic in adolescents in Cebu, Philippines.
Applications
Unspecified application
Species
Unspecified reactive species
Janet O Joseph,Michelle Ylade,Jedas Veronica Daag,Rosemary Aogo,Maria Vinna Crisostomo,Patrick Mpingabo,Lakshmanane Premkumar,Jacqueline Deen,Leah C Katzelnick
PLOS global public health 2:e0000619 PubMed36962464
2023
SARS-CoV-2 seroprevalence and risk factors among meat packing, produce processing, and farm workers.
Applications
Unspecified application
Species
Unspecified reactive species
Melissa D Klein,Michael Sciaudone,David Richardson,Roberto Lacayo,Colleen M McClean,Oksana Kharabora,Katherine Murray,Miriana Moreno Zivanovich,Stephen Strohminger,Rachel Gurnett,Alena J Markmann,D Ryan Bhowmik,Emperatriz Morales Salgado,Edwin Castro-Arroyo,Allison E Aiello,Ross M Boyce,Jonathan J Juliano,Natalie M Bowman
IJID regions 7:164-169 PubMed37034427
2023
Seroepidemiology and risk factors for SARS-CoV-2 infection among household members of food processing and farm workers in North Carolina.
Applications
Unspecified application
Species
Unspecified reactive species
Michael Sciaudone,Melissa K Cutshaw,Colleen M McClean,Roberto Lacayo,Oksana Kharabora,Katherine Murray,Stephen Strohminger,Miriana Moreno Zivanovich,Rachel Gurnett,Alena J Markmann,Emperatriz Morales Salgado,D Ryan Bhowmik,Edwin Castro-Arroyo,Ross M Boyce,Allison E Aiello,David Richardson,Jonathan J Juliano,Natalie M Bowman
Cell reports 38:110336 PubMed35090596
2022
SARS-CoV-2 mRNA vaccine induces robust specific and cross-reactive IgG and unequal neutralizing antibodies in naive and previously infected people.
Applications
Unspecified application
Species
Unspecified reactive species
Tara M Narowski,Kristin Raphel,Lily E Adams,Jenny Huang,Nadja A Vielot,Ramesh Jadi,Aravinda M de Silva,Ralph S Baric,John E Lafleur,Lakshmanane Premkumar
Science immunology 5: PubMed32527802
2020
The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients.
Applications
Unspecified application
Species
Unspecified reactive species
Lakshmanane Premkumar,Bruno Segovia-Chumbez,Ramesh Jadi,David R Martinez,Rajendra Raut,Alena Markmann,Caleb Cornaby,Luther Bartelt,Susan Weiss,Yara Park,Caitlin E Edwards,Eric Weimer,Erin M Scherer,Nadine Rouphael,Srilatha Edupuganti,Daniela Weiskopf,Longping V Tse,Yixuan J Hou,David Margolis,Alessandro Sette,Matthew H Collins,John Schmitz,Ralph S Baric,Aravinda M de Silva
medRxiv : the preprint server for health sciences : PubMed32511572
2020
The RBD Of The Spike Protein Of SARS-Group Coronaviruses Is A Highly Specific Target Of SARS-CoV-2 Antibodies But Not Other Pathogenic Human and Animal Coronavirus Antibodies.
Applications
Unspecified application
Species
Unspecified reactive species
Lakshmanane Premkumar,Bruno Segovia-Chumbez,Ramesh Jadi,David R Martinez,Rajendra Raut,Alena Markmann,Caleb Cornaby,Luther Bartelt,Susan Weiss,Yara Park,Caitlin E Edwards,Eric Weimer,Erin M Scherer,Nadine Roupael,Sri Edupuganti,Daniela Weiskopf,Longping V Tse,Yixuan J Hou,David Margolis,Alessandro Sette,Matthew H Collins,John Schmitz,Ralph S Baric,Aravinda M de Silva
NPJ vaccines 5:20 PubMed32194997
2020
Immunization of mice with chimeric antigens displaying selected epitopes confers protection against intestinal colonization and renal damage caused by Shiga toxin-producing .
Applications
Unspecified application
Species
Unspecified reactive species
David A Montero,Felipe Del Canto,Juan C Salazar,Sandra Céspedes,Leandro Cádiz,Mauricio Arenas-Salinas,José Reyes,Ángel Oñate,Roberto M Vidal
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