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AB97221

Goat Anti-Human IgG Fc

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(20 Publications)

Goat Anti-Human IgG Fc is a unconjugated secondary antibody that is suitable for Western blot, IHC, ICC and ELISA.

- Cited in over 10 publications

View Alternative Names

Immunoglobulin heavy constant gamma 1, Ig gamma-1 chain C region, Ig gamma-1 chain C region EU, Ig gamma-1 chain C region KOL, Ig gamma-1 chain C region NIE, IGHG1

Key facts

Host species

Goat

Target species

Human

Target isotype

IgG

Target specificity

Fc region

Minimal cross-reactivity
Pre-adsorbed

No

Applications

ELISA, IHC-P, ICC, WB

applications

Clonality

Polyclonal

Isotype

IgG

Specificity

By immunoelectrophoresis and ELISA this antibody reacts specifically with Human IgG. Cross reactivity with other immunoglobulins and light chains is less than 0.1%. This antibody may cross react with IgG from other species.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ICC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/1000 - 1/10000", "notes":"<p>Colorimetric; 1/1000 - 1/30000 Chemiluminescent</p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/100 - 1/500", "notes":"<p>for coating; 1/1000 - 1/30000 as primary</p>" }, "IHC-P": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/200 - 1/2000", "notes":"<p></p>" } } }
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Product details

This antibody reacts with Fc region of Human IgG.

When it comes to advancing your immunohistochemistry (IHC) research, Abcam offers comprehensive suite of IHC kits and secondary antibodies, designed to deliver precise and reliable results.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antiserum was solid phase adsorbed to ensure class specificity. This antibody was isolated by affinity chromatography using antigen coupled to agarose beads.
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

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Target data

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed : 20176268, PubMed : 22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed : 17576170, PubMed : 20176268). Mediates IgG effector functions on monocytes triggering ADCC of virus-infected cells.
See full target information IGHG1

Additional targets

IGHG2,IGHG3,IGHG4
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Publications (20)

Recent publications for all applications. Explore the full list and refine your search

ImmunoTargets and therapy 14:979-995 PubMed40937368

2025

Directed-Complement Activation as a Novel Immunotherapeutic Approach for HER2-Breast Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Carole Seguin-Devaux,Bianca Brandus,Jean-Marc Plesseria,Gilles Iserentant,Jean-Yves Servais,Aubin Pitiot,Georgia Kanli,Iris Behrmann,Rafaëla Schober,Jacques Zimmer,Jacques H M Cohen,Xavier Dervillez

Journal of molecular histology 56:302 PubMed40921925

2025

Tongxinluo alleviates myocardial ischemia-reperfusion injury by inhibiting the pyroptosis of endothelial cells via the NLRP3/Caspase-1/GSDMD signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xuan Wu,Yun-Long Hou,Tong-Xing Wang,Li-Ping Chang,Hong-Ru Zhou,Ming-Ye Wang,Yi-Ling Wu

FEBS letters 599:1442-1455 PubMed40313010

2025

Cytoplasmic delivery of antibodies through grafting a functional single complementarity-determining region loop.

Applications

Unspecified application

Species

Unspecified reactive species

Yerin Jeon,Juho Choi,Youngin Roh,Eunbin Lee,Luigie Villamante,Myung-Hee Kwon

Basic & clinical pharmacology & toxicology 135:693-704 PubMed39396908

2024

IL-4 promotes chondrogenesis of bone marrow mesenchymal stem cells and blockade of IL-4Rα retards the endochondral ossification during rat embryonic bone development.

Applications

Unspecified application

Species

Unspecified reactive species

Yimeng Hao,Qinghe Meng,Leilei Chang,Minglong Qiu,Jianxin Han,Zhiqin Wang,Changwei Li,Jing Ma,Xuemei Zhang

Nature communications 15:7141 PubMed39164224

2024

CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Guillem Pascual-Pasto,Brendan McIntyre,Margaret G Hines,Anna M Giudice,Laura Garcia-Gerique,Jennifer Hoffmann,Pamela Mishra,Stephanie Matlaga,Simona Lombardi,Rawan Shraim,Patrick M Schürch,Mark Yarmarkovich,Ted J Hofmann,Fatemeh Alikarami,Daniel Martinez,Matthew Tsang,Luis Gil-de-Gómez,Timothy T Spear,Kathrin M Bernt,Adam J Wolpaw,Dimiter S Dimitrov,Wei Li,Kristopher R Bosse

Frontiers in molecular biosciences 11:1346259 PubMed38756530

2024

The dispensability of V-V pairing and the indispensability of V domain integrity in the IgG1 secretion process.

Applications

Unspecified application

Species

Unspecified reactive species

Juho Choi,Yerin Jeon,Youngin Roh,Jeongyun Jang,Eunbin Lee,Luigie Villamante,Minjae Kim,Myung-Hee Kwon

Human vaccines & immunotherapeutics 20:2329446 PubMed38525945

2024

Production of monoclonal antibodies against botulinum neurotoxin in .

Applications

Unspecified application

Species

Unspecified reactive species

Kornchanok Sangprasat,Christine Joy I Bulaon,Kaewta Rattanapisit,Theerakarn Srisangsung,Perawat Jirarojwattana,Apidsada Wongwatanasin,Waranyoo Phoolcharoen

Frontiers in plant science 14:1149455 PubMed37711295

2023

Antitumor effect of plant-produced anti-CTLA-4 monoclonal antibody in a murine model of colon cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Christine Joy I Bulaon,Narach Khorattanakulchai,Kaewta Rattanapisit,Hongyan Sun,Nuttapat Pisuttinusart,Richard Strasser,Shiho Tanaka,Patrick Soon-Shiong,Waranyoo Phoolcharoen

Nanomaterials (Basel, Switzerland) 13: PubMed37299693

2023

Bioinspired Hierarchical Carbon Structures as Potential Scaffolds for Wound Healing and Tissue Regeneration Applications.

Applications

Unspecified application

Species

Unspecified reactive species

Soham D Parikh,Wenhu Wang,M Tyler Nelson,Courtney E W Sulentic,Sharmila M Mukhopadhyay

Clinical science (London, England : 1979) 137:47-63 PubMed36519413

2022

Sexual dimorphism in acute myocardial infarction-induced acute kidney injury: cardiorenal deteriorating effects of ovariectomy in premenopausal female mice.

Applications

Unspecified application

Species

Unspecified reactive species

Nada J Habeichi,Rana Ghali,Ali Mroueh,Abdullah Kaplan,Cynthia Tannous,Abdo Jurjus,Ghadir Amin,Mathias Mericskay,George W Booz,Ahmed El-Yazbi,Fouad A Zouein
View all publications
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