AB97220
Rabbit Anti-Human IgA alpha chain (HRP)
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(2 Publications)
Suitable for ICC, IHC-P, ELISA, WB. Ideal for western blot. Cited in 2 publications.
View Alternative Names
Immunoglobulin heavy constant alpha 1, Ig alpha-1 chain C region, Ig alpha-1 chain C region BUR, Ig alpha-1 chain C region TRO, IGHA1
Reactivity data
{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ICC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "IHC-P": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/200 - 1/2000", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/10000 - 1/100000", "notes":"<p>(as Primary).</p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/2000 - 1/25000", "notes":"<p>Colorimetric: 1/2000 - 1/20000; Chemiluminescent: 1/5000 - 1/25000</p>" } } }
Properties and storage information
Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antiserum was solid phase adsorbed to ensure class specificity. This antibody was isolated by affinity chromatography using antigen coupled to agarose beads and conjugated to Horse Radish Peroxidase (HRP).
Storage buffer
pH: 6.8 - 7.4 Preservative: 0.05% CMIT/MIT based preservative Constituents: 0.2% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Target data
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed : 20176268, PubMed : 22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed : 17576170, PubMed : 20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed : 2241915).
Additional targets
IGHA2
Publications (2)
Recent publications for all applications. Explore the full list and refine your search
Infection and immunity 91:e0050022 PubMed36715551
2023
A Staphylococcal Glucosaminidase Drives Inflammatory Responses by Processing Peptidoglycan Chains to Physiological Lengths.
Applications
Unspecified application
Species
Unspecified reactive species
Zachary J Resko,Caleb M Anderson,Michael J Federle,Francis Alonzo
Transboundary and emerging diseases 69:e734-e745 PubMed34655457
2021
Analysis of IgG, IgA and IgM antibodies against SARS-CoV-2 spike protein S1 in convalescent and vaccinated patients with the Pfizer-BioNTech and CanSinoBio vaccines.
Applications
Unspecified application
Species
Unspecified reactive species
Edgar A Melgoza-González,Diana Hinojosa-Trujillo,Mónica Reséndiz-Sandoval,Verónica Mata-Haro,Sofía Hernández-Valenzuela,Melissa García-Vega,Marlene Bravo-Parra,Aldo A Arvizu-Flores,Olivia Valenzuela,Edgar Velázquez,Alan Soto-Gaxiola,Martha B Gómez-Meza,Fernando Pérez-Jacobo,Luis Villela,Jesús Hernández
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