AB6715

Rabbit Anti-Human IgG H&L

Name: Rabbit Anti-Human IgG H&L secondary antibody (ab6715) | Abcam
Brand: Abcam Limited
SKU: AB6715
Price: 220 USD
Availability: InStock

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(39 Publications)

Suitable for Conjugation, IHC-Fr, IHC-P, IP, ID, ICC/IF, WB, ELISA. Cited in 39 publications.

View Alternative Names

Immunoglobulin heavy constant gamma 1, Ig gamma-1 chain C region, Ig gamma-1 chain C region EU, Ig gamma-1 chain C region KOL, Ig gamma-1 chain C region NIE, IGHG1

Key facts

Host species

Rabbit

Target species

Human

Target isotype

IgG

Target specificity

Heavy & Light chains

Minimal cross-reactivity

Pre-adsorbed

Applications

IP, ICC/IF, WB, IHC-Fr, ID, Conjugation, ELISA, IHC-P

applications

Clonality

Polyclonal

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "Conjugation": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" }, "IHC-Fr": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" }, "IHC-P": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" }, "IP": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" }, "ID": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" }, "ICC/IF": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/2000 - 1/10000", "notes":"" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/10000 - 1/50000", "notes":"" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/1000000", "notes":"" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification

Purification notes

This product was prepared from monospecific antiserum by immunoaffinity chromatography using Human IgG coupled to agarose beads.

Storage buffer

pH: 7.2 Preservative: 0.01% Sodium azide Constituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

Visit the General protocols
Visit the Troubleshooting

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Target data

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed : 20176268, PubMed : 22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed : 17576170, PubMed : 20176268). Mediates IgG effector functions on monocytes triggering ADCC of virus-infected cells.

See full target information IGHG1

Additional targets

IGHG3,IGHG4,IGHG2

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Publications (39)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 16:590 PubMed40925894

2025

CircPSD3 aggravates tumor progression by maintaining TCA cycle and mitochondrial function via regulating SUCLG2 in thyroid carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yijia Sun,Beinan Han,Jiawei Ge,Zijun Huo,Jin Li,Bo Lin,Xin Du,Yimin Zhang,Haiyan Weng,Shuang Yu,Yanbing Li,Haipeng Xiao,Xiaorong Lin,Shubin Hong

Materials today. Bio 34:102233 PubMed40917514

2025

Engineered biomimetic vesicles induce cuproptosis and disrupt efferocytosis for metastatic adenoid cystic carcinoma immunotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Mingyang Li,Wenjing Dong,Yuhan Cui,Jingwen Li,Chenyu Yang,Dongsheng Zhang,Xiao Fu

Cell death & disease 16:625 PubMed40825934

2025

Unraveling the Role of METTL3 in Helicobacter pylori-induced gastritis via m6A-CXCL1/NF-κB modulation.

Applications

Unspecified application

Species

Unspecified reactive species

Qiutong Lu,Zhaopeng Wang,Shuixian Cao,Huan Wang,Nianshuang Li,Yi Hu,Wuhui Ding,Wei Zuo,Junbo Hong

Journal of clinical biochemistry and nutrition 77:1-9 PubMed40777819

2025

TFAP2C activates PTGES through the NOTCH3 signaling pathway to affect gefitinib resistance in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Junmeng Xiao,Jianwei Cao,Lei Zhu,Jianbin Hou

Cell death discovery 11:197 PubMed40280903

2025

Single-cell multi-omics elucidates the role of RPS27-RPS24 fusion gene in osteosarcoma chemoresistance and metabolic regulation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiwei Tao,Pingan Zou,Zhengxu Yang,Tao Xiong,Zhi Deng,Qincan Chen

BJOG : an international journal of obstetrics and gynaecology 132:120-131 PubMed39992005

2025

Sigma-1 Receptor-Mediated High Mobility Group A1 Silencing Alleviates Endoplasmic Reticulum Stress-Induced Ovarian Granulosa Cell Apoptosis: An In Vitro Cell Experimental Study.

Applications

Unspecified application

Species

Unspecified reactive species

Lile Jiang,Shujun Yang,Cuilian Zhang

Cell biology and toxicology 40:108 PubMed39630363

2024

The mechanism of sevoflurane affecting ovarian cancer cell proliferation and migration by regulating RNA methylase TRDMT1 to activate the β-catenin pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaochen Huang,Xuewei Lao,Chengyan He,Jia Wang,Ying Pan

Redox biology 77:103392 PubMed39405980

2024

HJURP inhibits sensitivity to ferroptosis inducers in prostate cancer cells by enhancing the peroxidase activity of PRDX1.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjie Lai,Weian Zhu,Jianjie Wu,Jiongduan Huang,Xiaojuan Li,Yun Luo,Yu Wang,Hengda Zeng,Mingqiang Li,Xiaofu Qiu,Xingqiao Wen

Lipids in health and disease 23:326 PubMed39354487

2024

Glycerophospholipid-driven lipid metabolic reprogramming as a common key mechanism in the progression of human primary hepatocellular carcinoma and cholangiocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yanran Bi,Xihui Ying,Wanbin Chen,Jiahao Wu,Chunli Kong,Weiming Hu,Shiji Fang,Junchao Yu,Mengqian Zhai,Chengli Jiang,Minjiang Chen,Lin Shen,Jiansong Ji,Jianfei Tu

International heart journal 65:738-747 PubMed39085113

2024

Regulatory factor X7 Represses Ox-LDL-Induced Proliferation and Migration of VSMCs via SIRT4-Mediated Inactivation of JAK2/STAT3 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yinheng Hao,Wei Li

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Rabbit Anti-Human IgG H&L

Key facts

Host species

Target species

Target isotype

Target specificity

Minimal cross-reactivity

Pre-adsorbed

Applications

Clonality

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Additional targets

Publications (39)

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Product promise