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Potent, irreversible ornithine decarboxylase inhibitor (Ki = 39 μM). Depletes polyamines in vitro. Antineoplastic, cytotoxic and trypanocidal agent. Orally active. Active in vivo and in vitro.

Chemical Structure - Difluoromethylornithine, ornithine decarboxylase inhibitor (AB142422)

Difluoromethylornithine, ornithine decarboxylase inhibitor

MW 182.17 Da. Potent, irreversible ornithine decarboxylase inhibitor (Ki = 39 μM). Depletes polyamines in vitro. Antineoplastic, cytotoxic and trypanocidal agent. Orally active. Active in vivo and in vitro.

Difluoromethylornithine, ornithine decarboxylase inhibitor (ab142422) is unavailable

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