Note that this is a comparable WT GN, but not suitable as an isogenic control.

ioGlutamatergic Neurons have been reprogrammed from human induced pluripotent stem cells (iPSC) using opti-ox, a precise reprogramming technology. Human stem cells, within days, convert into consistent, mature, functional glutamatergic neurons providing a high quality human model for the study of neurological activity and disease.

ioGlutamatergic Neurons cultures consist mainly of glutamatergic neurons (>80%) characterised by the expression of the glutamate transporter genes VGLUT1 and VGLUT2 (see Figure 1). The minor remaining fraction of the neuronal population express marker genes of cholinergic neurons. A bulk RNA-seq analysis shows that ioGlutamatergic Neurons have a rostral CNS identity and express the classical cortical maker genes FOXG1 and TBR1 (data not shown).

In partnership with bit.bio

Karyotype: Normal

Seeding Density: 30,000 cells/cm²

Seeding compatibility: 6-, 12-, 24-, 96- and 384-well compatible

Quality control: ICC and gene expression analysis

Research applications: Academic research, Drug development, Neurotoxicology, Genetic screening (e.g. CRISPR screening).

This product is subject to limited use licenses from iPS Academia Japan Inc, TET Systems GmbH, ERS Genomics Limited and Sigma-Aldrich Co. LLC and is developed with Bit Bio patented technology. For full details of the licenses and patents please refer to our limited use license and patent pages.

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