PD-0325901, Sterile-Filtered

Potent, specific Autotaxin (ATX) inhibitor (IC50 = 2.8 nM in isolated enzyme assay; 101 nM in human whole blood). Modulates lysophosphatidic acid (LPA) levels in vivo and in vitro by directly inhibiting autotaxin. Orally available. Efficiently blocks inflammation-induced LPA production by >95% both in plasma and at the site of inflammation in rat adjuvant-induced arthritis model (30 mg/kg).

PF-8380, Autotaxin inhibitor

MW 478.3 Da. Potent, specific Autotaxin (ATX) inhibitor (IC50 = 2.8 nM in isolated enzyme assay; 101 nM in human whole blood). Modulates lysophosphatidic acid (LPA) levels in vivo and in vitro by directly inhibiting autotaxin. Orally available. Efficiently blocks inflammation-induced LPA production by >95% both in plasma and at the site of inflammation in rat adjuvant-induced arthritis model (30 mg/kg).

PF-8380, Autotaxin inhibitor (ab235548) is unavailable

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