2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Function
Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
Pathway
Secondary metabolite metabolism; quinolate metabolism.
Sequence Similarities
Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.
Alternative names
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, Picolinate carboxylase, ACMSD