5'-3' exoribonuclease 2
Function
Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).
Sequence Similarities
Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
Tissue Specificity
Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.
Cellular localization
- Nucleus
- Nucleolus
Alternative names
5'-3' exoribonuclease 2, DHM1-like protein, DHP protein, XRN2