5HT7 Receptor
Domain
Specificity for G(s) G alpha proteins is determined by the length of transmembrane regions 5 and 6 (TM5 and TM6).
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:8394362, PubMed:8397408, PubMed:8398139). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:8394362). HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:8394362).
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Thalamus, hypothalamus, and the hippocampal rudiments.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
5-hydroxytryptamine receptor 7, 5-HT-7, 5-HT7, 5-HT-X, GPRFO, Serotonin receptor 7