7a

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

Plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect (PubMed:33930332). Acts by binding to BST2 and sequestering it to perinuclear region, thereby preventing its antiviral function at cell membrane (PubMed:33930332). May specifically downregulate MHC-I allele HLA-A*02:01 (HLA-A2) (PubMed:36574644).

Poly-ubiquitinated by host with K63-linked polyubiquitin chains.

• Host cytoplasm
• Host perinuclear region
• Virion
• Host endoplasmic reticulum membrane
• Single-pass membrane protein
• Host endoplasmic reticulum-Golgi intermediate compartment membrane
• Single-pass type I membrane protein
• Host Golgi apparatus membrane
• Single-pass membrane protein

ORF7a protein, ORF7a, Accessory protein 7a, Protein U122, Protein X4, 7a

• swissprot:P0DTC7

Proteins

13744Da