7a
Domain
The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
Function
Plays a role as antagonist of host tetherin (BST2), disrupting its antiviral effect. Acts by binding to BST2 thereby interfering with its glycosylation. May suppress small interfering RNA (siRNA). May bind to host ITGAL, thereby playing a role in attachment or modulation of leukocytes.
Cellular localization
- Virion
- Host endoplasmic reticulum membrane
- Single-pass membrane protein
- Host endoplasmic reticulum-Golgi intermediate compartment membrane
- Single-pass type I membrane protein
- Host Golgi apparatus membrane
- Single-pass membrane protein
Alternative names
ORF7a protein, Accessory protein 7a, Protein U122, Protein X4, 7a