A2M
Developmental stage
Unlike the rat protein, which is an acute phase protein, this protein is always in circulation at high levels.
Function
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Sequence Similarities
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
Tissue Specificity
Secreted in plasma.
Cellular localization
- Secreted
Alternative names
CPAMD5, FWP007, A2M, Alpha-2-macroglobulin, Alpha-2-M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5