AADAC
Function
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
Post-translational modifications
Glycosylation is required for enzyme activity.
Sequence Similarities
Belongs to the 'GDXG' lipolytic enzyme family.
Tissue Specificity
Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder.
Cellular localization
- Endoplasmic reticulum membrane
- Single-pass type II membrane protein
- Microsome membrane
- Single-pass type II membrane protein
Alternative names
DAC, AADAC, Arylacetamide deacetylase