AASDHPPT
Function
Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN.
Sequence Similarities
Belongs to the P-Pant transferase superfamily. AcpS family.
Tissue Specificity
Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney.
Cellular localization
- Cytoplasm
- Cytosol
Alternative names
CGI-80, HAH-P, HSPC223, x0005, AASDHPPT, L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase, 4'-phosphopantetheinyl transferase, Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase, LYS5 ortholog, AASD-PPT