ABCA5
Developmental stage
Expressed in fetal liver, kidney and brain.
Function
Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity).
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCA family.
Tissue Specificity
Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta. Expressed in both the epithelial and mesenchymal compartments, present within the outer root sheath (ORS) of the hair follicle as well as dermal sheath (PubMed:24831815). Expressed in multiple regions of the brain, including the hippocampus, superior frontal and inferior temporal cortices (PubMed:25125465). Strongly expressed in neurons and moderately in microglia, with only weak expression in astrocytes and oligodendrocytes (PubMed:25125465).
Cellular localization
- Golgi apparatus membrane
- Multi-pass membrane protein
- Lysosome membrane
- Multi-pass membrane protein
- Late endosome membrane
- Multi-pass membrane protein
- Cell membrane
- Localized at cell membrane under high cholesterol levels.
Alternative names
KIAA1888, ABCA5, Cholesterol transporter ABCA5, ATP-binding cassette sub-family A member 5