ABCA8
Function
Isoform 1
Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate (PubMed:12379217). In vitro, also imports ochratoxin A (PubMed:12379217). Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes (PubMed:23560799).
Isoform 3
Catalyzes ATP-dependent efflux of cholesterol and taurocholate (PubMed:29300488). Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels (PubMed:28882873).
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCA family.
Tissue Specificity
Widely expressed with higher expression in heart, skeletal muscle and liver (PubMed:12379217, PubMed:28882873, PubMed:29300488). Highly expressed in the superior frontal white matter and inferior temporal white matter (PubMed:12379217).
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Basolateral cell membrane
- Predominantly expressed on the sinusoidal plasma membrane.
Alternative names
KIAA0822, ABCA8, ABC-type organic anion transporter ABCA8, ATP-binding cassette sub-family A member 8