ABCB1

Function

Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218).

Involvement in disease

Inflammatory bowel disease 13

IBD13

A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

None

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Tissue specificity

Expressed in liver, kidney, small intestine and brain.

Cellular localization

• Cell membrane
• Multi-pass membrane protein
• Apical cell membrane

Alternative names

• ATP-dependent translocase ABCB1
• ATP-binding cassette sub-family B member 1
• Multidrug resistance protein 1
• P-glycoprotein 1
• Phospholipid transporter ABCB1
• MDR1
• PGY1
• ABCB1

Database links

• entrezGene:5243
• omim:171050
• swissprot:P08183

Target type

Proteins

Primary research area

Cardiovascular

Molecular weight

141479Da