Abcc4
Developmental stage
Isoform 3
Ubiquitously expressed across all developmental stages.
Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates also the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4). The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (Probable). Confers resistance to anticancer agents (Probable).
Post-translational modifications
N-glycosylated; leading to substrate-selective effects on its transport activity.
Cellular localization
- Basolateral cell membrane
- Multi-pass membrane protein
- Apical cell membrane
- Multi-pass membrane protein
- Its localization to the basolateral or apical membranes is tissue-dependent.
Alternative names
Mrp4, Abcc4, ATP-binding cassette sub-family C member 4, Multidrug resistance-associated protein 4