PMP70

Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation. Has fatty acyl-CoA thioesterase and ATPase activities (By similarity). Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation (PubMed:10207018).

Ubiquitinated by PEX2 during pexophagy in response to starvation, leading to its degradation.

Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.

• Peroxisome membrane
• Multi-pass membrane protein

Pmp70, Pxmp1, ATP-binding cassette sub-family D member 3, 70 kDa peroxisomal membrane protein, PMP70

• swissprot:P16970

Proteins

Neuroscience

75316Da