ABCF1
Function
Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.
Post-translational modifications
Isoform 2 is phosphorylated at phosphoserine and phosphothreonine. Isoform 2 phosphorylation on Ser-109 and Ser-140 by CK2 inhibits association of EIF2 with ribosomes.
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
Tissue Specificity
Ubiquitous.
Cellular localization
- Isoform 2
- Cytoplasm
- Nucleus
- Nucleoplasm
- Nucleus envelope
Alternative names
ABC50, ABCF1, ATP-binding cassette sub-family F member 1, ATP-binding cassette 50, TNF-alpha-stimulated ABC protein