ABCG1

Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP (PubMed:17408620, PubMed:24576892). The lipid efflux is ALB-dependent (PubMed:16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (PubMed:17408620).

Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.

• Endoplasmic reticulum membrane
• Multi-pass membrane protein
• Golgi apparatus membrane
• Multi-pass membrane protein
• Cell membrane
• Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.

ABC8, WHT1, ABCG1, ATP-binding cassette sub-family G member 1, ATP-binding cassette transporter 8, White protein homolog

• entrezGene:9619
• omim:603076
• swissprot:P45844

Proteins

Metabolism

75592Da