ABCG4
Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) (PubMed:15240127, PubMed:33141061). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells (PubMed:27228027).
Sequence Similarities
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Tissue Specificity
Expressed specifically in the brain and the eye.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cytoplasmic vesicle membrane
- Multi-pass membrane protein
- Endosome membrane
- Multi-pass membrane protein
Alternative names
WHITE2, ABCG4, ATP-binding cassette sub-family G member 4