ABHD17A
Function
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards NRAS (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). May have depalmitoylating activity towards MAP6 (By similarity).
Post-translational modifications
Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization (PubMed:26701913). Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95 (By similarity).
Sequence Similarities
Belongs to the AB hydrolase superfamily. ABHD17 family.
Cellular localization
- Cell membrane
- Lipid-anchor
- Cytoplasmic side
- Endosome membrane
- Lipid-anchor
- Cytoplasmic side
- Cell projection
- Dendritic spine
- Postsynaptic density membrane
Alternative names
C19orf27, FAM108A1, ABHD17A, Alpha/beta hydrolase domain-containing protein 17A, Abhydrolase domain-containing protein 17A