ABHD17B
Function
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913).
Post-translational modifications
Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95.
Sequence Similarities
Belongs to the AB hydrolase superfamily. ABHD17 family.
Cellular localization
- Cell membrane
- Lipid-anchor
- Cytoplasmic side
- Recycling endosome membrane
- Lipid-anchor
- Cytoplasmic side
- Cell projection
- Dendritic spine
- Postsynaptic density membrane
Alternative names
C9orf77, FAM108B1, CGI-67, ABHD17B, Alpha/beta hydrolase domain-containing protein 17B, Abhydrolase domain-containing protein 17B