ACBD3
Domain
The central Gln-rich region (Q domain) is involved in binding to PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). The C-terminal GOLD domain is essential for giantin binding. The GOLD domain is also involved in homodimerization (PubMed:23572552).
(Microbial infection) The GOLD domain is involved in binding to the picornaviral protein 3A.
Function
Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356).
(Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites.
Tissue Specificity
Ubiquitous, with highest expression in testis and ovary.
Cellular localization
- Golgi apparatus membrane
- Peripheral membrane protein
- Cytoplasmic side
- Mitochondrion
- Also mitochondrial (via its interaction with PBR).
Alternative names
GCP60, GOCAP1, GOLPH1, ACBD3, Golgi resident protein GCP60, Acyl-CoA-binding domain-containing protein 3, Golgi complex-associated protein 1, Golgi phosphoprotein 1, PBR- and PKA-associated protein 7, Peripheral benzodiazepine receptor-associated protein PAP7